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Cg-Prkdcscid Il2rgtm1Wjl/SzJ. NOD scid gamma. CONGENIC, SPONTANEOUS MUTATION, TARGETED MUTATION MICE. Model Description; Disease & Phenotype; Terms of Use ... Searchfor: AboutUs GreenProcurementPolicy InVivosPrivacyStatement ProductsandServices Mice TaconicMice JAX®Mice Rats ContractBreedingServices Biospecimen&SurgicalServices TaconicBiosciencesProductsandServices IACUCConsultancyService JAX®Products 2022Pricing Quality HealthMonitoringSystem RodentHealthReports GeneticMonitoringSystem GeneticMonitoringReports CustomerServices HowtoOrder ContactUs OrderPolicies VolumeDiscountPricingProgramme TermsandConditions FAQs Announcements JAXNU/JInv JAXWebinarseries Comparingimmune-deficientMouseStrains B6Substrains NewJAXstrains COVID-19mousemodel ReusedTTC–PriceandTimeline News Events CareerOpportunities ResourceCentre InVivosPosters PresentationsandWebinars LiteratureLibrary Strainofthemonth NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ NODscidgamma CONGENIC,SPONTANEOUSMUTATION,TARGETEDMUTATIONMICE ModelDescriptionDisease&PhenotypeTermsofUse OVERVIEW AlsoKnownAs:NODscidgamma,NOD-scidIL2Rgnull,NOD-scidIL2Rgammanull,NSG TheseNSGmicecombinethefeaturesoftheNOD/ShiLtJbackground,theseverecombinedimmunedeficiencymutation(scid)andIL2receptorgammachaindeficiency.Asaresult,theseNSGmicelackmatureTcells,Bcells,orfunctionalNKcells,andaredeficientincytokinesignaling,leadingtobetterengraftmentofhumanhematopoieticstemcellsandperipheral-bloodmononuclearcellsthananyotherpublishedmousestrain.Recentpublicationshavedemonstratedthisstrain’soutstandingutilityinthestudiesofislettransplantation,hematopoieticstemcellsandcancerstemcells. DonatingInvestigator Dr.LeonardD.Shultz,TheJacksonLaboratory DetaileddescriptionandmoredetailsonTheJacksonLaboratory website Appearance albino RelatedGenotype:A/ATyrc/Tyrc   GENETICOVERVIEW GeneticBackground Generation N8F?+4pF24 (14-AUG-14) Il2rgtm1Wjl AlleleType GeneSymbol GeneName Targeted(Null/Knockout) Il2rg interleukin2receptor,gammachain Prkdcscid AlleleType GeneSymbol GeneName Spontaneous Prkdc proteinkinase,DNAactivated,catalyticpolypeptide DiseaseTerms Potentialmodelbasedongenehomologyrelationships.Phenotypicsimilaritytothehumandiseasehasnotbeentested. CombinedImmunodeficiency,X-Linked;CIDX(IL2RG) Immunodeficiency26withorwithoutNeurologicAbnormalities;IMD26(PRKDC) SevereCombinedImmunodeficiency,X-Linked;SCIDX1(IL2RG) ResearchAreasbyGenotype Thismousecanbeusedtosupportresearchinmanyareasincluding: ResearchTools Immunology,InflammationandAutoimmunityResearch B,T,andNKcelldeficiency InfectiousDisease HIV Genotype:Il2rgtm1Wjlrelated CancerResearch GrowthFactors/Receptors/Cytokines Immunology,InflammationandAutoimmunityResearch GrowthFactors/Receptors/Cytokines Genotype:Prkdcscidrelated Immunology,InflammationandAutoimmunityResearch Immunodeficiency BandTcelldeficiency Internal/OrganResearch LymphoidTissueDefects BandTcelldeficiency ResearchTools CancerResearch BandTcelldeficiency,xenograft/transplanthost ToxicologyResearch xenograft/transplanthost VirologyResearch BandTCellDeficiency AIDSresearchtool FurtherinformationcanbefoundonTheJacksonLaboratory’sWebsite   JAX®Mice,Products&ServicesConditionsofUse “MICE”meansmousestrains,theirprogenyderivedbyinbreedingorcrossbreeding,unmodifiedderivativesfrommousestrainsortheirprogenysuppliedbyTheJacksonLaboratory(“JACKSON”).“PRODUCTS”meansbiologicalmaterialssuppliedbyJACKSON,andtheirderivatives.“RECIPIENT”meanseachrecipientofMICE,PRODUCTS,orservicesprovidedbyJACKSONincludingeachinstitution,itsemployeesandotherresearchersunderitscontrol.MICEorPRODUCTSshallnotbe:(i)usedforanypurposeotherthantheinternalresearch,(ii)soldorotherwiseprovidedtoanythirdpartyforanyuse,or(iii)providedtoanyagentorotherthirdpartytoprovidebreedingorotherservices.AcceptanceofMICEorPRODUCTSfromJACKSONshallbedeemedasagreementbyRECIPIENTtotheseconditions,anddeparturefromtheseconditionsrequiresJACKSON’spriorwrittenauthorization. NoWarranty MICE,PRODUCTSANDSERVICESAREPROVIDED“ASIS”.JACKSONEXTENDSNOWARRANTIESOFANYKIND,EITHEREXPRESS,IMPLIED,ORSTATUTORY,WITHRESPECTTOMICE,PRODUCTSORSERVICES,INCLUDINGANYIMPLIEDWARRANTYOFMERCHANTABILITYORFITNESSFORAPARTICULARPURPOSE,ORANYWARRANTYOFNON-INFRINGEMENTOFANYPATENT,TRADEMARK,OROTHERINTELLECTUALPROPERTYRIGHTS. Incaseofdissatisfactionforavalidreasonandclaimedinwritingbyapurchaserwithinninety(90)daysofreceiptofmice,productsorservices,JACKSONwill,atitsoption,providecreditorreplacementforthemiceorproductreceivedortheservicesprovided. NoLiability InnoeventshallJACKSON,itstrustees,directors,officers,employees,andaffiliatesbeliableforanycausesofactionordamages,includinganydirect,indirect,special,orconsequentialdamages,arisingoutoftheprovisionofMICE,PRODUCTSorservices,includingeconomicdamageorinjurytopropertyandlostprofits,andincludinganydamagearisingfromactsornegligenceonthepartofJACKSON,itsagentsoremployees.Unlessprohibitedbylaw,inpurchasingorreceivingMICE,PRODUCTSorservicesfromJACKSON,purchaserorrecipient,oranypartyclaimingbyorthroughthem,expresslyreleasesanddischargesJACKSONfromallsuchcausesofactionordamages,andfurtheragreestodefendandindemnifyJACKSONfromanycostsordamagesarisingoutofanythirdpartyclaims. MICEandPRODUCTSaretobeusedinasafemannerandinaccordancewithallapplicablegovernmentalrulesandregulations. TheforegoingrepresentstheGeneralTermsandConditionsapplicabletoJACKSON’sMICE,PRODUCTSorservices.Inaddition,specialtermsandconditionsofsaleofcertainMICE,PRODUCTSorservicesmaybesetforthseparatelyinJACKSONwebpages,catalogs,pricelists,contracts,and/orotherdocuments,andthesespecialtermsandconditionsshallalsogovernthesaleoftheseMICE,PRODUCTSandservicesbyJACKSON,andbyitslicenseesanddistributors. AcceptanceofdeliveryofMICE,PRODUCTSorservicesshallbedeemedagreementtothesetermsandconditions.Nopurchaseorderorotherdocumenttransmittedbypurchaserorrecipientthatmaymodifythetermsandconditionshereof,shallbeinanywaybindingonJACKSON,andinsteadthetermsandconditionssetforthherein,includinganyspecialtermsandconditionssetforthseparately,shallgovernthesaleofMICE,PRODUCTSorservicesbyJACKSON. MissionStatement TobeSingapore'sLeadingsupplieroftop-qualityresearchanimals;dedicatedtomeetingtheexpectationsofthebiomedicalcommunitywithintegrityandexemplaryservicethroughouttheregion. 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