C57BL/6 Mice | Black 6 Inbred Mouse Strain - Taconic ...

C57BL/6, commonly called the B6 or Black 6, is among the most versatile inbred mouse strains and the preferred genetic background for several applications. FindYourModel FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery 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IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Contact searchsite searchsite eTACONIC TaconicFindyourmodelStandardStrainsandStocksBlack6(B6NTac) Black6(B6NTac)Inbred startanorder| printthispage| sharethispage OrderThisModelOR RequestaQuote CALL:888.822.6642 +4570230405(EUROPE) C57BL/6Background Model# Genotype Nomenclature B6-FC57BL/6NTac B6-MC57BL/6NTac ModelDescription Taconic'sB6ProvidesSuperiorPerformanceOneofthemostusedinbredmousemodels,theC57BL/6isusedinnearlyeveryresearchapplication,andit'scommonlyusedasthegeneticbackgroundfortransgenicmousemodels.Itisalsothepreferredmodelforstudyingdiet-inducedobesityandthechronicexperimentalautoimmuneencephalomyelitismodelofmultiplesclerosis.Popularresearchapplicationsincludeoncology,immunology,metabolicdisease,addictionandtoxicologyC57BL/6NTacisthepreferredC57BL/6substrainforgenerationofgeneticallyengineeredmodels,includingbytheKnockoutMouseProject(KOMP)andInternationalMousePhenotypingConsortium(IMPC)TheTaconicB6hassuperiorreproductiveperformancecomparedtootherB6substrains:superovulatedfemalesyieldahighnumberofembryosandmaleshavehigherspermfertilizationratesTheTaconicC57BL/6NTachasprovenmoreamenabletothedevelopmentofqualityembryonicstemcellscomparedtootherB6substrainsPopularstrainforsyngeneictumorexperiments;withasuiteofrelatedstrainsonthesamebackgroundformechanisticstudiesincludingRag2,Rag2/OT-I,Rag2/OT-IIandmanymoreHistoricaldatashowsthathydrocephalyoccursintheC57BL/6mousein0.05%ofthepopulationandmaynotbeevidentuntiltheanimalismorethantwomonthsofage.Origin:C57BL/6litterswerereceivedin1991atF151fromtheNIHAnimalGeneticResource.Cesareanderivedin1991atTaconic,afoundationcolonyismaintainedingnotobioticisolators.Originisasfollows:toNIHin1951fromJaxatF32;toJaxin1948fromHall.Availability:AvailableattheMurinePathogenFree™,OpportunistFree™,ExcludedFlora,andGermFreehealthstandards.Ordermodel#B6forMurinePathogenFree™,OpportunistFree™,andExcludedFlora.Ordermodel#GF-B6forGermFree.InquireaboutorderingmicepositiveornegativeforSegmentedFilamentousBacteria(SFB).Genetics: StrainProfile:Acy1f,Aladb,Car2a,Cas1g,Cd5b,Cd72b,Cd8ab,Cd8b1b,Ce2a,Es1a,Es3a,Esda,Ggc1b,Gpi1b,Gus-sb,H6pd1b,Hbaa,Hbbs,Hc1,Idh1a,Mod1b,Mup1b,Pep3a,Pgm1a,Trfb Immunology:H2b,Ptprcb,Thy1b,H2-T18b RetinalDegeneration:Crb1Rd8CoatColorLoci:a/a,B/B,C/CColor:BlackSpecies:MouseAnimalDiet:NIH#31MRodentDiet Pricing Selectapricingoption:USDollar Euro 2022PriceTableHealthStandards:MPF,EF,GFOrdermodel#B6forMurinePathogenFree™,OpportunistFree™,andExcludedFlora.Ordermodel#GF-B6forGermFree.B6FemalesB6-FMPFB6-FEFB6-FGFAgeinWeeksQuantity1-199200-9993to4$29.00$26.005to8$36.00$31.009to10$42.00$38.0011to12$49.00$43.00SpecializedInventoryAgeinWeeksQuantity1-1991-999UntimedPregnant$211.00RetiredBreeder$51.00Femalew/Litter$304.00TimedPregnant$297.00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.AgeinWeeksQuantity1-9993to4$50.005to6$63.007to8$73.009to10$81.0011to12$92.00SpecializedInventoryAgeinWeeksQuantity1-1991-999UntimedPregnant$303.00RetiredBreeder$87.00Femalew/Litter$406.00TimedPregnant$437.00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.AgeinWeeksQuantity1-2930-9994$534.00$508.005$594.00$566.006$616.00$585.007$643.00$612.008$670.00$637.009$710.00$677.0010$750.00$714.00SpecializedInventoryAgeinWeeksQuantity1-999UntimedPregnant$3,841.00RetiredBreeder$1,011.00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.B6MalesB6-MMPFB6-MEFB6-MGFAgeinWeeksQuantity1-199200-9993to4$29.00$26.005to8$36.00$31.009to10$42.00$38.0011$49.00$43.0012$55.00$43.00SpecializedInventoryAgeinWeeksQuantity1-99913to14$65.0015to16$75.0017to18$85.0019to20$95.0021to22$106.0023to24$115.0025to26$125.0027to31$146.0032to36$165.0037to40$186.0041to44$206.0045to48$225.0049to52$245.00RetiredBreeder$51.00AgeinWeeksQuantity1-9993to4$50.005to6$63.007to8$73.009to10$81.0011to12$92.00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder$87.00AgeinWeeksQuantity1-2930-9994$534.00$508.005$594.00$566.006$616.00$585.007$643.00$612.008$670.00$637.009$710.00$677.0010$750.00$714.00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder$1,011.00 2022PriceTableHealthStandards:MPF,OF,GFOrdermodel#B6forMurinePathogenFree™,OpportunistFree™,andExcludedFlora.Ordermodel#GF-B6forGermFree.B6FemalesB6-FMPFB6-FOFB6-FGFAgeinWeeksQuantity1-199200-9993to4€19,00€18,005to6€21,00€19,007to8€23,00€21,009to10€27,00€25,0011to12€33,00€30,00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder€31,00Femalew/Litter€176,00TimedPregnant€232,00AgeinWeeksQuantity1-9993to4€31,005to6€34,007to8€38,009to10€43,00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder€48,00AgeinWeeksQuantity1-2930-9994€532,00€507,005€595,00€566,006€614,00€585,007€641,00€612,008€668,00€636,009€710,00€677,0010€749,00€713,00B6MalesB6-MMPFB6-MOFB6-MGFAgeinWeeksQuantity1-1991-999200-9993to4€19,00€18,005to6€21,00€19,007to8€23,00€21,009to10€27,00€25,0011€33,00€30,0012€38,00€30,00SpecializedInventoryAgeinWeeksQuantity1-1991-99913to14€41,0015to16€50,0017to18€56,0019to20€63,0021to22€73,0023to24€79,0025to26€86,0027to31€100,0032to36€112,0037to40€125,0041to44€135,0045to48€149,0049to52€161,00RetiredBreeder€33,00AgeinWeeksQuantity1-9993to4€30,005to6€33,007to8€36,009to10€45,00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder€52,00AgeinWeeksQuantity1-2930-9994€532,00€507,005€595,00€566,006€614,00€585,007€641,00€612,008€668,00€636,009€710,00€677,0010€749,00€713,00 Licensing TermsofSaleandUseforBlack6(B6NTac) GermFreeBlack6aresoldsubjecttoTaconic'sTermsandConditionsforTaconic'sModels,ProductsandServicesandthefollowingtermsofuse: For-profitpurchasersmaynotbreedGermFreeBlack6excepttoobtainembryosorfetusesforresearchuse.Non-profitpurchasersmaybreedGermFreeBlack6foruseinprojectsatpurchaser'sinstitutionandonbehalfofnon-profitresearchersonly.GermFreeBlack6,progenyandmaterialsderivedfromthemwillnotbedistributedtothirdparties. MurinePathogenFree™,RestrictedFlora™,OpportunistFree,andExcludedFloraBlack6micearesoldsubjecttoTaconic'sTermsandConditionsforTaconic'sModels,ProductsandServices. HealthReport Viewtheproductionlocations(s)andtheaccompanyingcurrentIHMS™HealthReportandTaconicHealthStandardforthismodel PhenotypicData ExperimentalAutoimmuneEncephalomyelitis(EAE)inC57BL/6NTacmice RepresentativedataforExperimentalAutoimmuneEncephalomyelitis(EAE)inC57BL/6NTacprovidedbyBiomodels.Downloadthefulldatapackage. HistoricaldatashowsthathydrocephalyoccursintheC57BL/6mousein0.05%ofthepopulationandmaynotbeevidentuntiltheanimalismorethantwomonthsofage. C57BL/6NTacsubstrainscarrytheCrb1Rd8mutation.Retinaldegeneration8,isamildformofretinaldegenerationthataffectsvision.ThisrecessivemutationisasinglebasepairmutationintheCrb1gene,Crb1Rd8(Mehalowetal.2003)Theonsetofthephenotypeappearstobebetween2and6weeksofage(Pritchett-Corning,2012). C57BL/6Jmicepresentadeletion(~17Kbp)intheNicotinamideNucleotideTranshydrogenase(Nnt)gene.NntisatransmembraneproteinthatcatalyzestheinterconversionofNADHandNADPHinthemitochondria.StudiessuggestthatthepresenceofNntisessentialformitochondrialdefenseagainstoxidativestressandfornormalcellularmetabolism(Huangetal.2006).Taconic’sC57BLmice,includingC57BL/6JBomTac,C57BL/6NTacandC57BL/10SgSnAiTac,orourB6D2F1andB6129F1,donotcarrytheNntmutationwhichispresentinC57BL/6Jsub-strain. Behavioral Irwin StartleandPre-pulseInhibition OpenField Rotarod HotPlate Physiologic PhysiologicDatafrom2004 AutomatedClinicalChemistryAnalysis(ACCA) BodyWeight Hematology Immunology mBSA-InducedDelayedTypeHypersensitivity(DTH) Ovalbumin-InducedInVivoAntibodyProduction FACSAnalysisofSplenocytes ReproductiveData Averagelittersize:6-8 Mean#litters/female:7 Meanagebreederretired:10months Mean#daystolitter:22 GrowthChart Forsomeapplications,weightmaybecritical.Fororderswhereweightiscritical,pleaseplaceordersbyweight,notbyage.Taconiccanacceptordersbyweightforthismodel,exceptattheGFhealthstandard.Aminimum3gramspanisrequired.Allweightsareweightsattimeofpacking.Miceandratscanloseweightintransit.Ordersforspecificweightspanswillbeassessedanominalfee.Moredetailonweightorderpoliciesisavailable. n=500persexatMPF,RFandEFhealthstandardsfromallglobalcolonies.GFmicewilltypicallyweighslightlylessthantheweightsabove. Highandlowrepresentsmean+/-2standarddeviationsBasedonsamplesize,thechartsaboverepresent~90%ofthepopulation. Allgrowthcurvesrepresentanimalshousedinourbarriers,atourstandarddensityandfedNIH31-Mdiet.Variationsatcustomerfacilitieswillalterexpectedgrowthcurves. Growthchartsareprovidedonlyasaguide,ifaspecificweightcriteriaisneededpleaseorderanimalsbyweight. Customizethischartbyclickingthelegendelements,thenexploredownloadoptionsbyhoveringyourcursoroverthedownarrowtotherightofthecharttitle. Findyourmodel GEMsStandardStrainsandStocksInbredOutbredHybrid/CongenicStandardImmunodeficientsDietInducedMiceHumanizedImmuneSystemMiceTherapeuticAreas&Solutions2022PricingGuide 2022PricingGuideCreateyourcustomPricingGuide Whatourcustomerssay: “HookeusestheTaconicB6becausewegetmoreconsistentdiseasedevelopmentforExperimentalAutoimmuneEncephalomyelitis(EAE)thanwhenusingmicefromothervendors.”HookeLaboratories“TaconicBioscienceshadprovidedinvaluablesupporttoourcourseon"MouseDevelopment,StemCells&Cancer".ItwouldbedifficulttocontinuetoteachthiscourseatthelevelwecurrentlydowithoutTaconic'sexpertiseandC57BL/6mice.”ColdSpringHarbor“TheMRCMaryLyonCentrelocatedatMRCHarwellusesTaconic'sinbredmouselines(specificallyC57BL/6NTac)togenerateandcharacterizenewmousemodelsforuseinindividualresearchprojects,includinghigh-throughputinternationalprogramsandgenomeeditingefforts.”MRCHarwell ON-DEMANDWEBINAR BreedVs.Buy:What'sTheRightChoiceForYourLab? WatchNow WHITEPAPER SyngeneicMouseModelsforPreclinicalImmuno-OncologyResearch DownloadNow RelatedAnimalModels B6.SJLB6C3F1B6AlbinoB6AlbinoA++DietInducedObese(DIO)B6 RelatedServices AnimalAgingSurgicalModelsandServicesSpecialDietAdministration RelatedPublications GastrichelicobacterinfectioninducesaTh2phenotypebutdoesnotelevateserumcholesterolinmicelackinginduciblenitricoxidesynthase.ComparisonoftetraploidblastocystmicroinjectionofoutbredCrl:CD1(ICR),hybridB6D2F1/Tac,andinbredC57BL/6NTacembryosforgenerationofmicederivedfromembryonicstemcells.SearchallBlack6(B6NTac)publications TechnicalLibrary ProductSpecifications:B6 SuperovulationProtocol TaconicmicedonotcarrytheNntMutation AcademicGrantProgram Taconicinvitesscientistsinthenonprofitsectortoapplyforagranttosupporttheirresearch. ApplyToday SMARTSELECTPROGRAMValidateThisModelForYourStudyFindOutMore WhitePaper: TheMostImportantMouseintheWorld:TheUtilityandApplicationsofC57BL/6Models DownloadNow Close Welcome!Tellusalittleaboutyourself Hereweshowthechatwindow.