Systems biology - Latest research and news | Nature

Systems biology is the study of biological systems whose behaviour cannot be reduced to the linear sum of their parts' functions. Systems biology does not ... Skiptomaincontent Thankyouforvisitingnature.com.YouareusingabrowserversionwithlimitedsupportforCSS.Toobtain thebestexperience,werecommendyouuseamoreuptodatebrowser(orturnoffcompatibilitymodein InternetExplorer).Inthemeantime,toensurecontinuedsupport,wearedisplayingthesitewithoutstyles andJavaScript. Advertisement nature subjects systemsbiology Atom RSSFeed Systemsbiology Definition Systemsbiologyisthestudyofbiologicalsystemswhosebehaviourcannotbereducedtothelinearsumoftheirparts’functions.Systemsbiologydoesnotnecessarilyinvolvelargenumbersofcomponentsorvastdatasets,asingenomicsorconnectomics,butoftenrequiresquantitativemodellingmethodsborrowedfromphysics. Featured News&Views | 31March2022 Livingbuildingblocks KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 News&Views | 28March2022 Antibodiesasprogrammable,bipedalwalkers NatureComputationalScience,1-2 News&Views | 21March2022 Giveandtakeintheexometabolome KevinR.Stindt & MeganN.McClean NatureMicrobiology7,484-485 RelatedSubjects Bayesianinference Biobricks Biochemicalnetworks Bioenergetics Cellularnoise Complexity Computermodelling Computerscience Controltheory Criticality Differentialequations DNAcomputingandcryptography Dynamicnetworks Dynamicalsystems Emergence Evolvability Geneticcircuitengineering Geneticinteraction Genomicengineering Informationtheory Logicgates Metabolicengineering Modularity Molecularengineering Molecularfluctuations Multicellularsystems Multistability Nonlineardynamics Numericalsimulations Oscillators Populationdynamics Programminglanguage Proteinengineering Regulatorynetworks Reverseengineering Robustness Signalprocessing Single-cellimaging Software Standardization Stochasticmodelling Stochasticnetworks Syntheticbiology Systemsanalysis Timeseries Showmore LatestResearchandReviews Reviews 01April2022 | OpenAccess Currentprogressandopenchallengesforapplyingdeeplearningacrossthebiosciences Deeplearninghasenabledadvancesinunderstandingbiology.Inthisreview,theauthorsoutlineadvances,andlimitationsofdeeplearningin fivebroadareasandthefuturechallengesforthebiosciences. NicolaeSapoval,AmiraliAghazadeh & ToddJ.Treangen NatureCommunications13,1728 Research 01April2022 | OpenAccess Growthpromotionandantibioticinducedmetabolicshiftsinthechickengutmicrobiome Thisstudycomparesthefunctionalprofilesofthececalmicrobiomeamongchickensfedfourdifferentantimicrobialgrowthpromoters.Chickensreceivingnarasinexhibitedthelargestperformanceincreaseviaapparentnitrogenrecyclingbythecorececalmicrobiome. GermánPlata,NielsonT.Baxter & ArvindKumarMahajan CommunicationsBiology5,293 Research 01April2022 | OpenAccess Amulti-omicsapproachtoelucidatethemechanismsofactionofadietarymuramidaseadministeredtobroilerchickens GiorgioBrugaletta,AlessandraDeCesare & FedericoSirri ScientificReports12,5559 Research 31March2022 | OpenAccess Robustandtunablesignalprocessinginmammaliancellsviaengineeredcovalentmodificationcycles Phosphorylationnetworksarefrequentlyattheheartofcomplexcellulardecisionmaking.Heretheauthorsengineersyntheticphosphorylationdeviceswithfeedbackregulationinmammaliancellsanddemonstratehowtousethesetoachievetunableandrobustcontrolofcellbehaviours. RossD.Jones,YiliQian & RonWeiss NatureCommunications13,1720 Reviews | 31March2022 Thelivinginterfacebetweensyntheticbiologyandbiomaterialdesign ThisPerspectivereviewsthecomplementarydevelopmentsinsyntheticbiologyandbiomaterialsanddiscusseshowconvergenceofthesetwofieldscreatesapromisingdesignstrategyforthefabricationoftailoredlivingmaterialsformedicineandbiotechnology. AllenP.Liu,EricA.Appel & OvijitChaudhuri NatureMaterials21,390-397 Research 31March2022 | OpenAccess Drug-dependentgrowthcurvereshapingrevealsmechanismsofantifungalresistanceinSaccharomycescerevisiae Combinedgrowthcurveexperimentsandquantitativemodelingrevealantifungalresponsesofplanktonicyeast,providingafutureframeworktoexamineantimicrobialdrugresistance. LesiaGuinn,EvanLo & GáborBalázsi CommunicationsBiology5,292 AllResearch&Reviews NewsandComment Editorial | 31March2022 Materialscomealive Thedisseminationofsyntheticbiologyintomaterialsscienceiscreatinganevolvingclassoffunctional,engineeredlivingmaterialsthatcangrow,senseandadaptsimilartobiologicalorganisms. NatureMaterials21,379 News&Views | 31March2022 Livingbuildingblocks Aprototypicalbiocompositeblockcomprisingablendofbacteria,fungiandfeedstockcanbeassembledintohuman-sized,livingstructureswithself-healingandenvironmentalsensingcapabilities. KwokSoonWun,InYoungHwang & MatthewWookChang NatureMaterials21,382-383 Correspondence | 29March2022 Makingspaceforyoungspeakers TaeSeokMoon NatureChemicalBiology18,353 News&Views | 28March2022 Antibodiesasprogrammable,bipedalwalkers Stochasticmodelingofantibodybindingdynamicsonpatternedantigensubstratessuggeststheseparationdistancebetweenadjacentantigenscouldbeacontrolmechanismforthedirectedbipedalmigrationofboundantibodies. NatureComputationalScience,1-2 News&Views | 21March2022 Giveandtakeintheexometabolome Metabolicchangesinauxotrophsenrichthemicrobialcommunityexometabolomeandincreasedrugresistance. KevinR.Stindt & MeganN.McClean NatureMicrobiology7,484-485 News&Views | 15March2022 Definingcancergrowthbeyondthemitoticindex Tumourgrowthinvolvesanomaliesincellcyclegenesandemergentphenotypes,butthetumourproliferationrate(ormitoticindex)isdefinedbyjustonemarker,Ki-67.Astudynowintegratesexpressionpatternsofseveralmarkerstogeneratespatio-temporalmapsofcellproliferationincancertissues. ChandanKumar-Sinha & ArulM.Chinnaiyan NatureCellBiology24,285-287 AllNews&Comment Search Searcharticlesbysubject,keywordorauthor Showresultsfrom Alljournals Search Advancedsearch Quicklinks Explorearticlesbysubject Findajob Guidetoauthors Editorialpolicies