How is transfusion-related acute lung injury (TRALI) managed?

Transfusion-related acute lung injury (TRALI) is managed as follows: Immediately discontinue the transfusion while preserving venous access. ForYou News&Perspective Drugs&Diseases CME&Education Academy Video DecisionPoint  Specialty: Multispecialty Allergy&Immunology Anesthesiology BusinessofMedicine Cardiology CriticalCare Dermatology Diabetes&Endocrinology EmergencyMedicine FamilyMedicine Gastroenterology GeneralSurgery Hematology-Oncology HIV/AIDS HospitalMedicine InfectiousDiseases InternalMedicine Multispecialty Nephrology Neurology Ob/Gyn&Women'sHealth Oncology Ophthalmology Orthopedics Pathology&LabMedicine Pediatrics PlasticSurgery Psychiatry PublicHealth PulmonaryMedicine Radiology Rheumatology Transplantation Urology MedicalStudents Nurses Pharmacists Residents TodayonMedscape Edition: English Medscape English Deutsch Español Français Português UKNew Univadis LogIn SignUpIt'sFree! EnglishEdition Medscape English Deutsch Español Français Português UKNew Univadis X UnivadisfromMedscape Register LogIn NoResults NoResults Monday,May16,2022 ForYou News&Perspective Drugs&Diseases CME&Education Academy Video DecisionPoint close PleaseconfirmthatyouwouldliketologoutofMedscape. Ifyoulogout,youwillberequiredtoenteryourusernameandpasswordthenexttimeyouvisit. Logout Cancel https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly93d3cubWVkc2NhcGUuY29tL2Fuc3dlcnMvMjA2ODg1LTEwODY0My9ob3ctaXMtdHJhbnNmdXNpb24tcmVsYXRlZC1hY3V0ZS1sdW5nLWluanVyeS10cmFsaS1tYW5hZ2Vk processing.... Drugs&Diseases > Hematology > TransfusionReactionsQ&A Howistransfusion-relatedacutelunginjury(TRALI)managed? Updated:Jan12,2021 Author:SGeraldSandler,MD,FCAP,FACP;ChiefEditor:EmmanuelCBesa,MD more... References Share Email Print Feedback Close Facebook Twitter LinkedIn WhatsApp Answer Transfusion-relatedacutelunginjury(TRALI)ismanagedasfollows: Immediatelydiscontinuethetransfusionwhilepreservingvenousaccess. Patientswithmildepisodesshouldrespondtooxygenadministeredbynasalcatheterormask.Ifshortnessofbreathpersistsafteroxygenadministration,transferthepatienttoanintensivecaresettingwheremechanicalventilationcanbeemployed. Intheabsenceofsignsofacutevolumeoverloadorcardiogenicpulmonaryedema,diureticsarenotindicated. Noevidenceexiststhatcorticosteroidsorantihistaminesarebeneficial. Treatcomplicationswithspecificsupportivemeasures. ReadMore Didthisansweryourquestion? Yes No Additionalfeedback?(Optional) Submit Thankyouforyourfeedback! RelatedQuestions:   References FrazierSK,HigginsJ,BugajskiA,JonesAR,BrownMR.AdverseReactionstoTransfusionofBloodProductsandBestPracticesforPrevention.CritCareNursClinNorthAm.2017Sep.29(3):271-290.[Medline]. 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MediaGallery Rapidtesttodistinguishhematuriafromhemoglobinuria.Theonsetofredurineduringorshortlyafterabloodtransfusionmayrepresenthemoglobinuria(indicatinganacutehemolyticreaction)orhematuria(indicatingbleedinginthelowerurinarytract).Iffreshlycollectedurinefromapatientwithhematuriaiscentrifuged,redbloodcellssettleatthebottomofthetube,leavingaclearyellowurinesupernatant.Iftheredcolorisduetohemoglobinuria,theurinesampleremainsclearredaftercentrifugation. of 1 Tables BacktoList ContributorInformationandDisclosures Author SGeraldSandler,MD,FCAP,FACP ProfessorEmeritusofMedicineandPathology,GeorgetownUniversitySchoolofMedicine SGeraldSandler,MD,FCAP,FACPisamemberofthefollowingmedicalsocieties:AmericanAssociationofBloodBanks,CollegeofAmericanPathologists,InternationalSocietyofBloodTransfusionDisclosure:Nothingtodisclose. Coauthor(s) VivianaVJohnson,MD MedicalDirector,BloodBank,NavalMedicalCenter,Portsmouth VivianaVJohnson,MDisamemberofthefollowingmedicalsocieties:AmericanAssociationofBloodBanks,CollegeofAmericanPathologistsDisclosure:Nothingtodisclose. SpecialtyEditorBoard FranciscoTalavera,PharmD,PhD AdjunctAssistantProfessor,UniversityofNebraskaMedicalCenterCollegeofPharmacy;Editor-in-Chief,MedscapeDrugReferenceDisclosure:ReceivedsalaryfromMedscapeforemployment.for:Medscape. RonaldASacher,MBBCh,FRCPC,DTM&H ProfessorofInternalMedicineandPathology,Director,HoxworthBloodCenter,UniversityofCincinnatiAcademicHealthCenter RonaldASacher,MBBCh,FRCPC,DTM&Hisamemberofthefollowingmedicalsocieties:AmericanAssociationfortheAdvancementofScience,AmericanAssociationofBloodBanks,AmericanClinicalandClimatologicalAssociation,AmericanSocietyforClinicalPathology,AmericanSocietyofHematology,CollegeofAmericanPathologists,InternationalSocietyofBloodTransfusion,InternationalSocietyonThrombosisandHaemostasis,RoyalCollegeofPhysiciansandSurgeonsofCanadaDisclosure:Nothingtodisclose. ChiefEditor EmmanuelCBesa,MD ProfessorEmeritus,DepartmentofMedicine,DivisionofHematologicMalignanciesandHematopoieticStemCellTransplantation,KimmelCancerCenter,JeffersonMedicalCollegeofThomasJeffersonUniversity EmmanuelCBesa,MDisamemberofthefollowingmedicalsocieties:AmericanAssociationforCancerEducation,AmericanSocietyofClinicalOncology,AmericanCollegeofClinicalPharmacology,AmericanFederationforMedicalResearch,AmericanSocietyofHematology,NewYorkAcademyofSciencesDisclosure:Nothingtodisclose. AdditionalContributors PradyumnaDPhatak,MBBS,MD Chair,DivisionofHematologyandMedicalOncology,RochesterGeneralHospital;ClinicalProfessorofOncology,RoswellParkCancerInstitute PradyumnaDPhatak,MBBS,MDisamemberofthefollowingmedicalsocieties:AmericanSocietyofHematologyDisclosure:ReceivedhonorariafromNovartisforspeakingandteaching. Acknowledgements TheviewsexpressedinthisarticlearethoseoftheauthorsanddonotnecessarilyreflecttheofficialpolicyorpositionoftheDepartmentoftheNavy,DepartmentofDefense,northeU.S.Government. FindUsOn About AboutMedscape PrivacyPolicy EditorialPolicy Cookies DoNotSellMyPersonalInformation TermsofUse AdvertisingPolicy HelpCenter Membership BecomeaMember AboutYou ProfessionalInformation Newsletters&Alerts App Medscape WebMDNetwork MedscapeLiveEvents WebMD MedicineNet eMedicineHealth RxList WebMDCorporate Editions English Deutsch Español Français Português Allmaterialonthiswebsiteisprotectedbycopyright,Copyright©1994-2022byWebMDLLC.Thiswebsitealsocontainsmaterialcopyrightedby3rdparties. Close