MegaBOLT: Bioinformatics analysis accelerator-MGI-Leading ...

文章推薦指數： 80 %
投票人數：10人

MegaBOLT supports the analysis of Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), and Panel Sequencing on Germline or Somatic data. It is 20 times ... BioinformaticsanalysisacceleratorLocation：Home / Products ProductDescription MegaBOLTbioinformaticsanalysisaccelerator(hereinaftercalledMegaBOLT)isanMGIself-developedandMPS-concentratedhardwareacceleratingsystemforbioinformaticsanalysis.MegaBOLTsupportstheanalysisofWholeGenomeSequencing(WGS),WholeExomeSequencing(WES),andPanelSequencingonGermlineorSomaticdata.Itis20timesfasterthanthetraditionalapproach.Fast,integrated,easytouse,andeconomicareMegaBOLT’smostprominentfeatures. MegaBOLTproductsincludetheworkstationandrackserver,whichcanbeappliedtovariousscenariosofallscales. Laboratories Hospitals Researchinstitutes Enterprises Fast MegaBOLTadoptsCPUandFPGAheterogeneouscomputingtoaccelerateanalysis.ItacceleratesalgorithmssuchasSOAPnuke,Minimap2,BWA,GATKHaplotypeCaller+MuTect2throughmulti-streamandhighlyparallelizedcomputingarchitecture,whichcontributestoa10Xto20Xspeedupinmassivedataanalysis. Multi-taskschedulingsystemacceleration Integratedwiththeself-developedmulti-taskschedulingsystem,MegaBOLTsupportssimultaneousmulti-taskcomputingononesingleserver.Thecomputingefficiencyisfurtherimprovedby16%to28%. Germline MegaBOLT MegaBOLT-scheduler WGS30XNA12878DNBSEQ WGS400XNA12878DNBSEQ *Themeanvalueiscalculatedbyexecutingthesame4tasksatthesametime. Precision 01.Precision Afterspeedup,theanalysisprecisionremainssteadfast.MegaBOLTisalsoconfiguredwithadeeplearningvariantcallingmodule,MegaBOLT-DV,whichisoptimizedbyalgorithmsandspecifiedneuralnetworkmodeltraining.WhenMegaBOLTisusedincombinationwithPCR-FreelibrarypreparationandMGIDNBSEQ™sequencingtechnologies,thehumanWGSvariantcallingprecisioncanreachSNP99.9%andINDEL99%. 02.Deeplearningmakingsequencingmorecost-effective Thedeeplearningvariantcallingmodule,MegaBOLT-DV,helpstogreatlyreducethesequencingdepthandcostwithoutaffectingtheanalysisprecision. Comparedwiththetraditionalvariantcallingresultsof30XPCRdata,SNPof15XPCR-FreedatafromMegaBOLT-DVisclosewhileINDELbetter. Tradition MegaBOLT-DV Integrated Integratedwiththeself-developedlaboratoryinformationmanagementsystemZLIMS,MegaBOLTrealizesfullyautomatedsequencingandanalysis.ItcanworktogetherwithMGIDNBSEQ™sequencersorsequencersofotherplatforms. Laboratorydevicemanagementandreal-timemonitoring Sampleinformationrecordingandtracking Datatransmissionandmanagement Analysistaskschedulingandcomputing Analysisresult/reportmanagementandvisualization Easytouse TheWebdesignmakesMegaBOLTsimpleandeasytouse.Youcanjustclickacoupleofbuttonstosubmitataskandchecktheresultsonthewebsite.Inthiscase,abioinformatictechnicalbackgroundisnolongernecessary.     Economic Withaprominentspeedupincomputingandrigidcontroloverhardwareprimecost,aMegaBOLTserverworkslike10normalcomputersintotalandiswithoutdoubthighlycost-effective. HeterogeneouscomputingsystemofCPUandFPGA accommodateshigh-speedsequenceanalysis MegaBOLT’sheterogeneouscomputingsystemofCPUandFPGA,fulfillingfromFASTQinputofsequencingdatatoBAMoutputofalignmentresultandVCF/gVCFoutputofvariantcallingresult. TheFPGAhardwarelogiccircuitisspeciallydesignedforbioinformaticscomputingtoincreaseitsanalysisspeed.Weadoptamulti-streamcomputingarchitectureforFPGAanddividedataintosmallergranulesforhigherefficiency.Wealsofurtherstreamlinedthewholeprocessanddevelopedahighlyparallelizedcomputingarchitecture,thusrealizinghighspeedWGS/WESanalysisandcomputing. Comparedwiththecommonanalysisworkflow,MegaBOLTstandsoutforthefollowingfeatures: SpecializedFPGAhardwarelogiccircuitforbioinformaticscomputing Multi-streamcomputingarchitecture Highlyparallelizedcomputingarchitecture RelatedDocuments MegaBOLTUserManual MegaBOLT_Quick_Start_GuideMegaBOLT_User_ManualMegaBOLT_User_Manual_AdvancedMegaBOLT_User_Manual_ZLIMSMegaBOLT-ZLIMSOperationVideo MegaBOLTAnalysisReportCases WGSAnalysreport WESAnalysisreport MegaBOLTDataDescriptionsandScripts MegaBOLTScripts SupplementaryInformation QuickContact

請為這篇文章評分？

延伸文章資訊