NOG mouse - Wikipedia

A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA) in ... NOGmouse FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch ANOG(NOD/Shi-scid/IL-2Rγnull)mouseisanewgenerationofseverelyimmunodeficientmouse,developedbyCentralInstituteforExperimentalAnimals(CIEA)in2000.TheNOGmouseacceptsheterologouscellsmuchmoreeasilycomparedwithanyothertypeofimmunodeficientrodentmodels,suchasnudemouseandNOD/scidmouse.Thus,themousecanbethebestmodelasahighlyefficientrecipientofhumancellstoengraft,proliferateanddifferentiate.[1]Thisuniquefeatureoffersagreatopportunityforenhancingtherapyresearchesofcancer,leukemia,visceraldiseases,AIDS,andotherhumandiseases.Italsoprovidesapplicationsforcancer,infection,regeneration,andhematologyresearches. Contents 1Origin 2Characteristics 3Applicationstomedicalresearches 4Seealso 5References 6Externallinks Origin[edit] TheNOGmousewasgeneratedinCIEAin2000byback-crossmatingofC57BL/6J-IL-2RγnullmousethatwasoriginallydevelopedbyKazuoSugamura,aprofessorofTohokuUniversity,toNOD/Shi-scidmousethatwasdevelopedinCIEA. Characteristics[edit] NoactivityofTcell,BcellandNKcell Reducedcomplementsystemactivity Dysfunctionofmacrophage Dysfunctionofdendriticcell Noleakiness:noincidenceofT,Bcellswithaging Noincidenceoflymphoma NOGmousehasmultipleimmunodeficienciesthatareprincipallyderivedfromthreestrainsofmice:1)NOD/Shiinbredstrain,2)SCID,3)IL-2Rγnull.Theseinclude: ReducedinnateimmunityderivedfromaNODinbredstrain,whichinvolvesamacrophagedysfunction,andadefectofcomplementhemolyticactivityandreducedNKactivity.[2]TheNOD/ShiinbredstrainwasfirstdiscoveredbyMakinoetal.asautoimmunenon-obese-typediabetesmice.[3][4] LackoffunctionalTandBcellsthatisderivedfromamutationofproteinkinase(Prkdc:proteinkinase,DNAactivated,catalyticpolypeptide),whichisthecausativegeneofthescidmutation[5][6] LackofNKcells,dendriticcelldysfunctions,andotherunknowndeficienciesduetoinactivationoftheIL-2Rγgene.[7][8][9][10] Applicationstomedicalresearches[edit] Cancer InfectiousDiseases RegenerativeMedicine Hematology Humanizedmouse Seealso[edit] Nudemouse SCIDmouse References[edit] ^M.Itoand,et al.(2002)."NOD/SCID/γnullmouse:anexcellentrecipientmousemodelforengraftmentofhumancells".Blood.100(9):3175–3182.doi:10.1182/blood-2001-12-0207.PMID 12384415. ^Shultz,L.D.;Schweitzer,P.A.;Christianson,S.W.;Gott,B.;Schweitzer,I.B.;Tennent,B.;McKenna,S.;Mobraaten,L.;Rajan,T.V.;et al.(1995)."MultipledefectsininnateandadaptiveimmunologicfunctioninNOD/LtSz-scidmice".JournalofImmunology.154(1):180–191.PMID 7995938. ^Kikutani,H.;Makino,S.(1992).Themurineautoimmunediabetesmodel:NODandrelatedstrains.AdvImmunol.AdvancesinImmunology.Vol. 51.pp. 285–322.doi:10.1016/S0065-2776(08)60490-3.ISBN 9780120224517.PMID 1323922. ^Makino,S.;Kunimoto,K.;Muraoka,Y.;Mizushima,Y.;Katagiri,K.;Tochino,Y.(1980)."Breedingofanon-obese,diabeticstrainofmice".JikkenDobutsu.29(1):1–13.doi:10.1538/expanim1978.29.1_1.PMID 6995140. ^Bosma,G.C.;Custer,R.P.;Bosma,M.J.(1983)."Aseverecombinedimmunodeficiencymutationinthemouse".Nature.301(5900):527–530.Bibcode:1983Natur.301..527B.doi:10.1038/301527a0.PMID 6823332.S2CID 4267981. ^Kirchgessner,C.U.;Patil,C.K.;Evans,J.W.;Cuomo,C.A.;Fried,L.M.;Carter,T.;Oettinger,M.A.;Brown,J.M.(1995)."DNA-dependentkinase(p350)asacandidategeneforthemurineSCIDdefect".Science.267(5201):1178–1183.Bibcode:1995Sci...267.1178K.doi:10.1126/science.7855601.PMID 7855601.S2CID 29017462. ^Ikebe,M.;Miyakawa,K.;Takahashi,K.;Ohbo,K.;Nakamura,M.;Sugamura,K.;Suda,T.;Yamamura,K.;Tomita,K.;et al.(1997)."Lymphohaematopoieticabnormalitiesandsystemiclymphoproliferativedisorderininterleukin-2receptorgammachain-deficientmice".IntJExpPathol.78(3):133–148.doi:10.1046/j.1365-2613.1997.230356.x.PMC 2694530.PMID 9306921. ^Ohbo,K.;Suda,T.;Hashiyama,M.;Mantani,A.;Ikebe,M.;Miyakawa,K.;Moriyama,M.;Nakamura,M.;Katsuki,M.;et al.(1996)."Modulationofhematopoiesisinmicewithatruncatedmutantoftheinterleukin-2receptorgammachain".Blood.87(3):956–967.doi:10.1182/blood.V87.3.956.bloodjournal873956.PMID 8562967. ^Ohteki,T.;Fukao,T.;Suzue,K.;Maki,C.;Ito,M.;Nakamura,M.;Koyasu,S.(1999)."Interleukin-12dependentinterferon-gproductionbyCD8a+lymphoiddendriticcells".JExpMed.189(12):1981–1986.doi:10.1084/jem.189.12.1981.PMC 2192968.PMID 10377194. ^Sugamura,K.;Asao,H.;Kondo,M.;Tanaka,N.;Ishii,N.;Ohbo,K.;Nakamura,M.;Takeshita,T.(1996)."Theinterleukin-2receptorgammachain:itsroleinthemultiplecytokinereceptorcomplexesandTcelldevelopmentinXSCID".AnnuRevImmunol.14:179–205.doi:10.1146/annurev.immunol.14.1.179.PMID 8717512. Externallinks[edit] NOGmouse BaseNOGMousehttp://www.taconic.com/nog TK-NOGhttp-//www.taconic.com/12907 hGM-CSF/hIL3-NOG-http://www.taconic.com/13395 B2m-NOG-http://www.taconic.com/13439 CIEASite-https://www.ciea.or.jp/en/nog_mouse.html Retrievedfrom"https://en.wikipedia.org/w/index.php?title=NOG_mouse&oldid=1048069674" Categories:Immunologymice Navigationmenu Personaltools NotloggedinTalkContributionsCreateaccountLogin Namespaces ArticleTalk English Views ReadEditViewhistory More Search Navigation MainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonate Contribute HelpLearntoeditCommunityportalRecentchangesUploadfile Tools WhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitem Print/export DownloadasPDFPrintableversion Languages TiếngViệt Editlinks