Sprague Dawley Rat Model | Taconic Biosciences

Sprague Dawley rats are used in virtually all aspects of biomedical research, including toxicology and pharmacology. FindYourModel FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Contact searchsite searchsite eTACONIC FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Contact searchsite searchsite eTACONIC TaconicFindyourmodelStandardStrainsandStocksSpragueDawley® SpragueDawley®Outbred startanorder| printthispage| sharethispage OrderThisModelOR RequestaQuote CALL:888.822.6642 +4570230405(EUROPE) Model# Genotype Nomenclature SD-FNTac:SD SD-MNTac:SD ModelDescription UsedinvirtuallyalldisciplinesofbiomedicalresearchincludingtoxicologyandpharmacologyExcellentreproductiveperformancemakestheSDratagoodmodelforgeneratingtimedpregnantfemales*NowofferedattheExcludedFlorahealthstandardinadditiontoMurinePathogenFree™andRestrictedFlora™.ExcludedFloraandRestrictedFlora™SDratsareusefulashealthsentinels,cleanfostersorwhereco-housedwithimmunodeficient/geneticallymodifiedmodels. Origin:TheSpragueDawley®outbredmodelwasdevelopedbySpragueDawley,Inc.NIHreceivedstockfromSpragueDawley,Incin1945.Theratsaremaintainedasanoutbredclosedcolony.TaconicreceivedstockfromtheNIHAnimalGeneticResourcein1970.TheratswererefreshedwithNIHGeneticResourcestockin1998.CoatColorLoci:TyrcColor:AlbinoSpecies:RatAnimalDiet:NIH#31MRodentDiet Pricing Selectapricingoption:USDollar Euro 2022PriceTableHealthStandards:MPF,EFSDFemalesSD-FMPFSD-FEFAgeinWeeksQuantity1-9993to4$28.005to6$30.007to8$44.009to10$46.0011$51.0012$58.0013$65.0014$71.0015$77.00SpecializedInventoryAgeinWeeksQuantity1-999UntimedPregnant$121.00RetiredBreeder$51.00Femalew/Litter$162.00TimedPregnant$165.00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.AgeinWeeksQuantity1-9993to4$63.005to6$66.007to8$74.009to10$90.0011$102.0012$115.0013$128.0014$140.0015$153.00SpecializedInventoryAgeinWeeksQuantity1-999UntimedPregnant$236.00Femalew/Litter$243.00TimedPregnant$297.00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.SDMalesSD-MMPFSD-MEFAgeinWeeksQuantity1-9993to4$28.005to6$30.007to8$45.009to10$54.0011$66.0012$76.0013$87.0014$96.0015$111.0016$119.0017$128.00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder$63.00AgeinWeeksQuantity1-9993to4$55.005to6$57.007to8$83.009to10$107.0011$119.0012$143.0013$156.0014$168.0015$193.00 2022PriceTableHealthStandards:MPF,EFSDFemalesSD-FMPFSD-FEFAgeinWeeksQuantity1-199200-9993to4€23,00€19,005to6€29,00€26,007to8€26,00€31,009to10€42,00€38,0011€50,00€52,0012€58,00€59,0013€66,00€67,0014€73,00€73,00SpecializedInventoryAgeinWeeksQuantity1-999UntimedPregnant€183,00RetiredBreeder€95,00Femalew/Litter€243,00TimedPregnant€263,00*Untimedpregnantrequestsarefilledwithlategestationpregnantfemales.Pupsmaybedeliveredintransit.AgeinWeeksQuantity1-9993to4€56,005to6€79,007to8€92,009to10€112,0011€123,0012€137,0013€150,0014€162,0015€175,0016€187,0017€200,00SpecializedInventoryAgeinWeeksQuantity1-999Femalew/Litter€248,00SDMalesSD-MMPFSD-MEFAgeinWeeksQuantity1-199200-9993to4€23,00€20,005to6€31,00€29,007to8€45,00€40,009to10€58,00€52,0011€66,00€59,0012€73,00€67,0013€82,00€73,0014€90,00€80,00SpecializedInventoryAgeinWeeksQuantity1-999RetiredBreeder€95,00AgeinWeeksQuantity1-9993to4€56,005to6€81,007to8€107,009to10€136,0011€147,0012€161,0013€174,0014€186,0015€199,0016€212,0017€224,00 HealthReport Viewtheproductionlocations(s)andtheaccompanyingcurrentIHMS™HealthReportandTaconicHealthStandardforthismodel GrowthChart Forsomeapplications,weightmaybecritical.Fororderswhereweightiscritical,pleaseplaceordersbyweight,notbyage.Taconiccanacceptordersbyweightforthismodel.FororderssourcedfromUSproductionaminimum10gramspanisaccepted.Duetocolonysizerestriction,aminimum20gramspanfororderssourcingfromDanishproductionfacilitiesisrequired.Allweightsareweightsattimeofpacking.Miceandratscanloseweightintransit.Ordersforspecificweightspanswillbeassessedanominalfee.Moredetailonweightorderpoliciesisavailable. n=500persexatMPF,RFandEFhealthstandardsfromallglobalcolonies.Datacollected2013-15. HighandLowrepresentmean+/-1standarddeviation.Basedonsamplesizethechartsaboverepresents~68%ofthepopulation. Allgrowthcurvesrepresentanimalshousedinourbarriers,atourstandarddensityandfedNIH31-Mdiet.Variationsatcustomerfacilitieswillalterexpectedgrowthcurves. Growthchartsareprovidedonlyasaguide,ifaspecificweightcriteriaisneededpleaseorderanimalsbyweight. Customizethischartbyclickingthelegendelements,thenexploredownloadoptionsbyhoveringyourcursoroverthedownarrowtotherightofthecharttitle. PhenotypicData Averagelittersize:10 SDPhysiologicalDataSummary(April2004;N=10/group): Parameter Units Sprague Dawley®Males Sprague Dawley®Females SerumChemistry Avg±S.D.     Calcium mg/dL 12.3±0.4 11.4±3.5 Phosphorous mg/dL 12.6±1.1 12.4±1.4 Glucose mg/dL 82.4±11.3 93.2±10.3 Creatinine mg/dL 0.3±0.1 0.3±0.1 BUN mg/dL 9.1±1.4 13.6±3.0 TotalBilirubin mg/dL 0.1±0.0 0.1±0.0 ALK U/L 227.7±36.1 142.5±33.9 ALTU/L U/L 29.3±3.4 22.5±3.9 TotalProtein g/dL 6.4±0.2 6.7±0.2 BloodCounts Erythron       RedBloodCells X106/uL 6.9±0.3 7.7±0.3 NucleatedRBC X106/uL 0 0 Hemoglobin g/dL 14.5±0.8 16.1±0.6 Hematocrit % 48.3±2.3 51.2±2.6 MCV fL 69.9±1.7 66.9±0.9 MCH pG 20.9±1.3 21.0±1.1 MCHC % 29.9±1.6 31.4±1.9 Platelets       Platelets X103/uL 1358.0±123.8 1262.2±278.4 Leukogram       WhiteBloodCells x103/uL 9.4±3.2 6.0±1.5 Neutrophil x103/uL 0.9±0.5 0.4±0.3 Bands x103/uL 0 0 Lymphocyte x103/uL 8.3±2.9 5.5±1.4 Monocytes x103/uL 0.3±0.3 0.1±0.1 Eosinophil x103/uL 0 0 Basophils x103/uL 0 0 Others x103/uL 0 0 OrganWeights       Stomach g 2.02±0.12 1.54±0.17 Ileum g 6.19±0.62 4.83±0.35 Colon g 0.77±0.37 0.85±0.21 Lungs g 1.69±0.14 1.31±0.19 Heart g 1.24±0.14 0.90±0.10 Liver g 11.37±1.12 7.17±0.62 Spleen/Pancreas g 1.58±0.15 1.17±0.23 Kidney(L) g 1.08±0.1 0.82±0.08 Kidney(R) g 1.09±0.09 0.85±0.08 Testes(L) g 1.33±0.17 - Testes(R) g 1.33±0.14 - Ovary(L) g - 0.08±0.01 Ovary(R) g - 0.08±0.01 Urinalysis       Glucose mg/dL Negative Negative Blood - Negative Negative pH - 6.75±0.35 6.7±0.4 Protein mg/dL N/A N/A SpecificGravity - 1.0195±0.0068 1.0155±0.0079 PhenotypingProcedures: AnimalReceiptandMaintenance Aquantityoftwentyrats(tenmalesandtenfemales)wassubmittedfortesting,strainidentifiedasLineSpragueDawley®(NTac:SD),age7weeks.RatswerereceivedatRBU3,TaconicBiotechnology,AlbanyNYandacclimatedforthreedaysonirradiatedNIH#31MRodentDietandsterilizedwateradlib,sterilecontactbedding(paperchip)anda12:12light:darkcycle.Allanimalsappearednormalduringthisperiodandroutinehealthsurveillanceofthiscolonydetectednomicrobialpathogens.Ratswereassignedstudyuniqueidentificationnumbers(males1-10,females11-20).   Urinalysis Allratswereplacedinmetaboliccagesandanovernighturinesamplewascollected.UrineanalysiswasperformedusingMultistix10SG(Bayer).Stripswerereadandrecordedasperthemanufacturer'sinstructions,andtheresultsarepresentedinTable2.   ClinicalChemistryandHematology AterminalbloodsamplewastakenfromCarbonDioxide-anesthetizedratsviacardiacpuncture.Thecollectedbloodwasdividedintotwosamples.OnesamplewastreatedwithEDTAandstoredat4°Cforhematologicalevaluation.Anothersamplewasallowedtoclotat4°Cfor30minutes,andthencentrifugedat7000rpmfor10minutes,andtheserumwasdecantedandfrozenat-80°Cforclinicalchemistryanalysis.Aslidesmearwasmadefromasingledropofwholeblood.Frozenserum,chilledwholebloodandslidesweredeliveredtoLabCorp(RTP,NC)foranalysis;theresultsarepresentedinTable3.Unlessotherwiseindicated,serumchemistrydataisgeneratedfromaHitachi717automatedanalyzerandhematologicaldataisgeneratedfromaCelldyne3500.WBCdifferentialcountsareperformedmanually.   NecropsyandOrganWeights Allratswereeuthanizedandbodyweightswererecorded.Representativetissueswerecollected,weighed,andimmersionfixedin10%NeutralBufferedFormalin.TissuesweredeliveredtotheTaconicAnmedlab(Rockville,MD)forhistologicalpreparationandevaluation.TabulationoforganweightsispresentedinTable4.Thepathologist’ssummaryanddetailedhistologicaldescriptionsfollow.   Discussion Allanimalswerethriftyonarrivalandappearedclinicallynormal.Locomotorbehaviorwasnormalandtherewerenovisiblelesionsordischargesatthemucousmembranes.Alltissuesappearednormalongrossnecropsyevaluationandweightswerewithinnormallimits.Therewerenounusualfindingsuponcollectionofthesetissuesnorotherwiseobservedinthebodycavities. Theoverallprofileoftheseratsisconsistentwithexpectationsofageneral-purposerat.Noneoftheparametersareindicativeofimpairedsystemfunction. OneYearGrowthChart TaconicSpragueDawley®RatsAverageControlGroupBodyWeightinGrams OneYearToxicologyStudy(N=20) WeeksofAge 6 7 8 9 10 Female 152.71 184.13 209.71 227.55 241.11 Male 163.01 225.98 276.15 306.93 336.53 WeeksofAge 11 12 13 14 15 Female 256.33 260.37 271.94 279.08 291.5 Male 361.71 378.11 396.8 412.86 431.21 WeeksofAge 16 17 18 22 26 Female 295.22 298.41 303.42 315.48 335.41 Male 441.56 454.14 461.01 491.98 514.05 WeeksofAge 30 34 38 42 46 Female 350.74 357.83 368.19 383.44 392.05 Male 528.94 544.33 556.88 568.96 568.41 WeeksofAge 50 54 58 Female 408.44 421.01 426.79 Male 579.1 584.42 577.79 Findyourmodel GEMsStandardStrainsandStocksInbredOutbredHybrid/CongenicStandardImmunodeficientsDietInducedMiceHumanizedImmuneSystemMiceTherapeuticAreas&Solutions2022PricingGuide 2022PricingGuideCreateyourcustomPricingGuide ON-DEMANDWEBINAR BreedVs.Buy:What'sTheRightChoiceForYourLab? WatchNow RelatedServices SurgicalModelsandServicesMurineBiospecimenCollection RelatedPublications Amethionineaminopeptidase-2inhibitor,PPI-2458,forthetreatmentofrheumatoidarthritis.Anatomicalanddevelopmentalpatternsoffacilitativeglucosetransportergeneexpressionintheratkidney.SearchallSpragueDawley®publications TechnicalLibrary SpragueDawley®Rat SMARTSELECTPROGRAMValidateThisModelForYourStudyFindOutMore ON-DEMANDWEBINAR TheLaboratoryRat:Biology,Reproduction,andUniqueApplications WatchNow Close Welcome!Tellusalittleaboutyourself Hereweshowthechatwindow.