Glucocorticoid-Remediable Aldosteronism - Lippincott

Glucocorticoid remediable aldosteronism (GRA) appears to be the most common monogenic form of human hypertension. As a result of chimeric gene duplication, ... January-February2004-Volume12-Issue1 Previous Abstract Next Abstract FullTextAccessforSubscribers: IndividualSubscribers Loginforaccess InstitutionalUsers AccessthroughOvid® NotaSubscriber? Buy Subscribe RequestPermissions Youcanreadthefulltextofthisarticleifyou: Selectanoption LogIn BuyArticle Subscribe Content&Permissions AccessthroughOvid LogIn AccessthroughOvid ArticleasEPUB ExportAllImagestoPowerPointFile AddtoMyFavorites Colleague'sE-mailisInvalid YourName: Colleague'sEmail: Separatemultiplee-mailswitha(;). Message: Thoughtyoumightappreciatethisitem(s)IsawinCardiologyinReview. Yourmessagehasbeensuccessfullysenttoyourcolleague. Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime. EndNoteProciteReferenceManager Savemyselection OriginalArticlesMcMahon,GrahamT.MB,BCh,MRCPI;Dluhy,RobertG.MD AuthorInformation FromtheDivisionofEndocrinology,Diabetes&Hypertension,Brigham&Women’sHospital,andHarvardMedicalSchool,Boston,Massachusetts. Reprints:GrahamT.McMahon,MB,BCh,DivisionofEndocrinology,Diabetes&Hypertension,Brigham&Women’sHospital,221LongwoodAve.,RFB2,Boston,MA02115.E-mail:[email protected] CardiologyinReview: January2004-Volume12-Issue1-p44-48 doi:10.1097/01.crd.0000096417.42861.ce Buy Metrics Abstract Glucocorticoidremediablealdosteronism(GRA)appearstobethemostcommonmonogenicformofhumanhypertension.Asaresultofchimericgeneduplication,aldosteroneisectopicallysynthesizedinthezonafasciculataoftheadrenalglandunderthecontrolofadrenocorticotropin(ACTH).Affectedindividualsaretypicallyhypertensive,oftenwithonsetinyouth,anddemonstraterefractorinesstostandardantihypertensivessuchasangiotensin-convertingenzymeinhibitorsandβ-blockers.GRAsubjectsarenormokalemicbutoftendevelophypokalemiawhentreatedwithapotassium-wastingdiuretic.Analysisofaffectedkindredshasdemonstratedahighprevalenceofearlycerebralhemorrhage,largelyasaresultofaneurysms.Identificationofaffectedindividualsshouldallowdirectneurovascularscreeningandtargetedantihypertensivetherapy. ©2004LippincottWilliams&Wilkins,Inc. Source Glucocorticoid-RemediableAldosteronism CardiologyinReview12(1):44-48,January-February2004. Full-Size Email +Favorites Export ViewinGallery Colleague'sE-mailisInvalid YourName: Colleague'sEmail: Separatemultiplee-mailswitha(;). Message: Thoughtyoumightappreciatethisitem(s)IsawinCardiologyinReview. Yourmessagehasbeensuccessfullysenttoyourcolleague. Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime. ArticleasEPUB ExportAllImagestoPowerPointFile AddtoMyFavorites Colleague'sE-mailisInvalid YourName: Colleague'sEmail: Separatemultiplee-mailswitha(;). Message: Thoughtyoumightappreciatethisitem(s)IsawinCardiologyinReview. Yourmessagehasbeensuccessfullysenttoyourcolleague. Someerrorhasoccurredwhileprocessingyourrequest.Pleasetryaftersometime. EndNoteProciteReferenceManager Savemyselection Keywords glucocorticoid-remediablealdosteronism ,dexamethasone-suppressiblehyperaldosteronism ,monogenichypertension ,hyperaldosteronism SearchforSimilarArticles Youmaysearchforsimilararticlesthatcontainthesesamekeywordsoryoumay modifythekeywordlisttoaugmentyoursearch. glucocorticoid-remediablealdosteronism\r,dexamethasone-suppressiblehyperaldosteronism\r,monogenichypertension\r,hyperaldosteronism ArticlesinPubMedbyGrahamT.McMahon,MB,BCh,MRCPI ArticlesinGoogleScholarbyGrahamT.McMahon,MB,BCh,MRCPI OtherarticlesinthisjournalbyGrahamT.McMahon,MB,BCh,MRCPI Dataistemporarilyunavailable.Pleasetryagainsoon. Thiswebsiteusescookies.Bycontinuingtousethiswebsiteyouaregivingconsenttocookiesbeingused.ForinformationoncookiesandhowyoucandisablethemvisitourPrivacyandCookiePolicy. Gotit,thanks!