HNRNP Protein | Heterogeneous Nuclear Ribonucleoprotein

HNRNP, also known as Heterogeneous nuclear ribonucleoproteins, are complexes of RNA and protein found in the nucleus of cells during gene transcription and ... HNRNP Home RecombinantProteins HNRNP RecombinantProteins Cytokines GrowthFactors Chemokines CDAntigens Neurotrophins Hormones Enzymes ViralAntigens RecombinantProteins NaturalProteins MonoclonalAntibodies PolyclonalAntibodies Name Description Cat# Pricings Quantity HNRNPA1Human MoreInfo HeterogeneousNuclearRibonucleoproteinA1HumanRecombinant PRO-1038 5µg($50) 20µg($130) 1mg($3600) ShippedwithIcePacks AddtoCart BacktoTop HNRNPABHuman MoreInfo HeterogeneousNuclearRibonucleoproteinA/BHumanRecombinant PRO-1731 2µg($50) 10µg($130) 1mg($5200) ShippedwithIcePacks AddtoCart BacktoTop HNRNPCHuman MoreInfo HeterogeneousNuclearRibonucleoproteinCHumanRecombinant PRO-177 1µg($50) 5µg($130) 50µg($1200) ShippedwithIcePacks AddtoCart BacktoTop HNRNPKHuman MoreInfo HeterogeneousNuclearRibonucleoproteinKHumanRecombinant PRO-1539 5µg($50) 20µg($130) 1mg($2700) ShippedwithIcePacks AddtoCart BacktoTop AboutHNRNP/HeterogeneousNuclearRibonucleoprotein: HNRNP,alsoknownasHeterogeneousnuclearribonucleoproteins,arecomplexesofRNAandproteinfoundinthenucleusofcellsduringgenetranscriptionandsubsequentpost-transcriptionalmodificationofthenewlysynthesizedRNA(pre-mRNA).Proteinsthatareboundtoapre-mRNAmoleculeserveasasinglethatthepre-mRNAhasn’tbeenprocessedyet,andthismeansthatitisn’treadyfortransportationtothecytoplasm. HNRNPMechanismMostRNA-bindingproteinsinthenucleusexistasheterogeneousribonucleoproteinparticles,withmatureRNAbeingexportingfromthenucleusassoonasitisready.Aftersplicinghasoccurred,theproteinsremainboundtosplicedintronsandtargetthemfordegradation. HNRNPFunctionhnRNPsarealsointegraltothe40ssubunitoftheribosome,makingthemimportantforcytoplasmtranslationofmRNA.hnRNPsaremainlyfoundinthenucleusthankstotheirownnuclearlocalizationsequences(NLS).ImmunofluorescencemicroscopywithhnRNP-specificantibodiesshowsnucleoplasmiclocalizationoftheseproteinswithlittlestaininginthenucleolusorcytoplasm.ThisisthankstoitsmajorroleinbindingtofreshlytranscribedRNAs.hnRNPslocalizespredominantlytotheborderregionsofchromatintogainaccesstothesenascentRNAs. HNRNPInteractionsGroupsofproteinsinvolvedinhnRNPcomplexesarecalledheterogeneousribonucleoproteins.TheseareregulatedbyphosphorylationcatalyzedbyproteinkinaseAandareresponsibleforsuppressingRNAsplicingataparticularexonbyblockingaccessofthespliceosometothepolypyrimidinetract,andincludeproteinKandpolypyrimidinetract-bindingprotein(PTB).InteractionsbetweenattachedhnRNPsmayencouragecertainsplicingcombinationswhileinhibitingothers.