Primary Aldosteronism (Hyperaldosteronism) | Cedars-Sinai

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Primary aldosteronism (hyperaldosteronism) is a condition that occurs when the adrenal glands produce too much aldosterone, the hormone responsible for ... Skiptocontent Cedars-Sinai HealthLibrary PrimaryAldosteronism(Hyperaldosteronism) Share Email Print Conditions&Treatments SymptomChecker VideoLibrary PreventionGuidelines HealthCalculators RiskAssessments PrimaryAldosteronism(Hyperaldosteronism) Notwhatyou'relookingfor? StartNewSearch ABOUT DIAGNOSIS TREATMENT Overview Primaryaldosteronism(hyperaldosteronism)isaconditionthatoccurswhentheadrenalglandsproducetoomuchaldosterone,thehormoneresponsibleforbalancingpotassiumandsodiuminthebody. Overproductionofaldosteronecausesthebodytoretainmoresodiumandlosepotassium,whichleadstoelevatedbloodpressure.Patientswiththisconditionareatincreasedriskofheartdiseaseandstroke. Symptoms Themainsymptomexperiencedbypatientswithprimaryaldosteronismismoderatetoseverehighbloodpressure,whichisoftenresistanttodrugtreatmentsandaccompaniedbylowpotassiumlevels. Othersymptomsinclude: Fatigue Headaches Muscleweakness Numbness Sporadictemporaryparalysis CausesandRiskFactors Manycasesofprimaryaldosteronismarecausedbyabenigntumorinanadrenalgland;somearecausedbyoveractivityofbothadrenalglands,aconditionknownasbilateraladrenalhyperplasia. Inrarecases,theconditionmaybecausedbycanceroustumorsintheouterlayerofanadrenalgland,orbyageneticconditionknownasglucocorticoid-remediablealdosteronism. Theconditionismostcommoninpeoplebetweentheagesof30and50. Diagnosis Whendiagnosingprimaryaldosteronism,thephysicianoftenwillfirstorderabloodtesttodeterminethepatient’saldosteroneandreninlevels.Reninisanenzymereleasedbythekidneysthathelpsregulatebloodpressure.Ifelevatedamountsofaldosteroneandminimalamountsofreninarefound,thiscouldbeasignofprimaryaldosteronism,andothertestsmaybeorderedtoconfirmthediagnosis. Thesetestsmayincludesaltloading,whichinvolvestheintakeofhighlevelsofsodiumfollowedbybloodandurinetestingtodeterminehowthebodyishandlingthesaltandrespondingwithaldosteroneproduction. AdditionaltestingcanincludeComputedTomography(CT)orAdrenalVeinSampling(AVS),inwhichanexperiencedradiologist,suchastheprofessionalsatCedars-Sinai’sHypertensionCenter,usesacathetertotakebloodsamplesfrombothadrenalglandstomeasurealdosteroneproduction.  Treatment Whenprimaryaldosteronismiscausedbyabenigntumorontheadrenalgland,theconditionmaybetreatedeithersurgicallyorwithmedication. Ifsurgeryisthebestoption,anadrenalectomycanbeperformedtoremoveboththetumorandtheadrenalglandtowhichitisattached.Thisoftenpermanentlyresolvestheprimaryaldosteronismandthephysicianwillfollowthepatient’sprogressclosely,adjustingoreliminatingthepatient’smedicationsasneeded. Whensurgeryisnotanoption,aldosterone-blockingmedicationscanbeusedtomanagethecondition.However,thesedonotcuretheconditionandmustbetakenregularlytomanagethesymptoms. Iftheprimaryaldosteronismisduetooveractiveadrenalglands,medicationcanhelpmanagethecondition.Medicationsknownasmineralocorticoidreceptorantagonistsblocktheeffectsofaldosteroneinthepatient’sbodyandhelplowerbloodpressureandincreasepotassiumlevels. ©2000-2021TheStayWellCompany,LLC.Allrightsreserved.Thisinformationisnotintendedasasubstituteforprofessionalmedicalcare.Alwaysfollowyourhealthcareprofessional'sinstructions. Notwhatyou'relookingfor? StartNewSearch WantMoreInformation? Cedars-Sinaihasarangeofcomprehensivetreatmentoptions. SeeOurPrograms LookingforaPhysician? Chooseadoctorandscheduleanappointment. FindaDoctor NeedHelp? 1-800-CEDARS-1 (1-800-233-2771) Available24HoursADay ScheduleaCallback ExpertCareforLife™StartsHere AdultPrimaryCare PediatricPrimaryCare UrgentCare NeedHelp? 1-800-CEDARS-1 (1-800-233-2771) ScheduleaCallback LookingforaPhysician Chooseadoctorandscheduleanappointment. FindaDoctor Share Email Print Cedars-Sinai HealthLibrary PrimaryAldosteronism(Hyperaldosteronism) DOCTORS LOCATIONS MYCS-LINK



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