Benralizumab - Wikipedia

Benralizumab, sold under the brand name Fasenra, is a monoclonal antibody medication which is developed by MedImmune for the treatment of asthma. Benralizumab FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch BenralizumabMonoclonalantibodyTypeWholeantibodySourceHumanized(frommouse)TargetCD125ClinicaldataPronunciationben"raliz'uemabTradenamesFasenraAHFS/Drugs.comMonographMedlinePlusa618002Licensedata EU EMA: byINN US DailyMed: Benralizumab Pregnancycategory AU:B1 RoutesofadministrationSubcutaneousATCcodeR03DX10(WHO)LegalstatusLegalstatus AU:S4(Prescriptiononly) CA:℞-only[1] UK:POM(Prescriptiononly) US:℞-only EU:Rx-only[2] IdentifiersCASNumber1044511-01-4 NDrugBankDB12023 YChemSpidernoneUNII71492GE1FXKEGGD09874 NChemicalandphysicaldataFormulaC6492H10060N1724O2028S42Molarmass146056.45 g·mol−1 NY (whatisthis?)  (verify) Benralizumab,soldunderthebrandnameFasenra,isamonoclonalantibodymedicationwhichisdevelopedbyMedImmuneforthetreatmentofasthma.Itisdirectedagainstthealpha-chainoftheinterleukin-5receptor(CD125).[3][4] TwophaseIIIclinicaltrialsofbenralizumabreportedmeetingtheirprimaryendpointsin2016.[5][6]ItwasapprovedbytheUSFoodandDrugAdministrationinNovember2017forthetreatmentofsevereeosinophilicasthma.[7]ItwasgranteddesignationasanorphandrugbytheFoodandDrugAdministrationfortreatmentofeosinophilicoesophagitisinAugust2019.[8] References[edit] ^"SearchPage-DrugandHealthProductRegister".23October2014. ^"FasenraEPAR".EuropeanMedicinesAgency(EMA).Retrieved13October2020. ^StatementonaNonproprietaryNameArchived2016-08-15attheWaybackMachineadoptedbytheUSANCouncil:Benralizumab ^CatleyMC(September2010)."Asthma&COPD--IQPC'sSecondConference".IDrugs.13(9):601–4.PMID 20799138. ^AstraZeneca'sbenralizumabreducesasthmaexacerbationsupto51%intwolate-statestudies.Sept2016 ^NairP,WenzelS,RabeKF,BourdinA,LugogoNL,KunaP,et al.(June2017)."OralGlucocorticoid-SparingEffectofBenralizumabinSevereAsthma".TheNewEnglandJournalofMedicine.376(25):2448–2458.doi:10.1056/NEJMoa1703501.PMID 28530840. ^"Fasenra(benralizumab)receivesUSFDAapprovalforsevereeosinophilicasthma".AstraZeneca.2017-11-14. ^"FasenragrantedUSOrphanDrugDesignationforeosinophilicoesophagitis".www.astrazeneca.com.Retrieved2019-10-29. Externallinks[edit] "Benralizumab".DrugInformationPortal.U.S.NationalLibraryofMedicine. vteMonoclonalantibodiesfortheimmunesystemImmunesystemHuman Immunosuppression:Abrilumab Adalimumab# Anifrolumab Atorolimumab Avelumab Avdoralimab Belimumab Bleselumab Brodalumab Camidanlumabtesirine Carlumab Cemiplimab Dupilumab Eldelumab Emapalumab Fresolimumab Golimumab Ianalumab† Lanadelumab Lenzilumab Lerdelimumab Lirentelimab Lirilumab Mavrilimumab Metelimumab Morolimumab Namilumab Oleclumab Oxelumab§ Pamrevlumab Placulumab Relatlimab† Sarilumab Sifalimumab Tabalumab Tezepelumab Ulocuplumab Varlilumab Immuneactivation:Ipilimumab Durvalumab Nivolumab Tremelimumab† Urelumab Other:Bertilimumab Zanolimumab Combination:Nivolumab/relatlimab Mouse Afelimomab Elsilimomab Faralimomab Gavilimomab Inolimomab Maslimomab Nerelimomab Odulimomab Telimomabaritox Vepalimomab Zolimomabaritox Chimeric Andecaliximab† Basiliximab Clenoliximab Galiximab Gomiliximab Infliximab Keliximab Lumiliximab Priliximab Teneliximab Vapaliximab Humanized Immunosuppressive:Apolizumab§ Aselizumab Atezolizumab Benralizumab Camrelizumab† Cedelizumab Certolizumabpegol Crizanlizumab Daclizumab Eculizumab Efalizumab‡ Epratuzumab Erlizumab Etrolizumab† Fontolizumab Inebilizumab Itolizumab Lampalizumab† Letolizumab Ligelizumab† Lulizumabpegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab Omalizumab Ozoralizumab Pascolizumab Pateclizumab Pembrolizumab Pexelizumab Pidilizumab Plozalizumab PRO140† Quilizumab Ravulizumab Reslizumab Rontalizumab Rovelizumab Ruplizumab Samalizumab Satralizumab Siplizumab Spartalizumab† Talizumab Teplizumab Tislelizumab Tocilizumab Toralizumab Tregalizumab Vatelizumab Vedolizumab Visilizumab Vobarilizumab TGN1412§ Immuneactivation:Dostarlimab Other:Ibalizumab Chimeric+humanized Otelixizumab Sutimlimab InterleukinHuman Bermekimab Brazikumab Briakinumab Canakinumab Fezakinumab Fletikumab Guselkumab Secukinumab Sirukumab Tralokinumab Ustekinumab Humanized Anrukinzumab Bimekizumab Clazakizumab Gevokizumab Ixekizumab Mirikizumab† Lebrikizumab Olokizumab† Perakizumab Risankizumab Spesolimab Tildrakizumab Veterinary Lokivetmab InflammatorylesionsMouse Besilesomab Fanolesomab‡ Lemalesomab Sulesomab #WHO-EM ‡Withdrawnfrommarket Clinicaltrials: †PhaseIII §NevertophaseIII vteInterleukinreceptormodulatorsIL-1 Agonists:Interleukin1(α,β) Mobenakin Pifonakin Antagonists:AF-12198 Anakinra IL-1RA Isunakinra Antibodies:Canakinumab Gevokizumab Lutikizumab Decoyreceptors:Rilonacept(IL-1Trap) IL-2 Agonists:Adargileukinalfa Aldesleukin Celmoleukin Denileukindiftitox Interleukin2 Pegaldesleukin Teceleukin Tucotuzumabcelmoleukin Antibodies:Basiliximab Daclizumab(dacliximab) Inolimomab IL-3 Agonists:Daniplestim Interleukin3 Leridistim Milodistim Muplestim Promegapoietin IL-4 Agonists:Binetrakin Interleukin4 Interleukin13 Antagonists:Pitrakinra Antibodies:Dupilumab Pascolizumab IL-5 Agonists:Interleukin5 Antagonists:YM-90709 Antibodies:Benralizumab Mepolizumab Reslizumab Antisenseoligonucleotides:TPIASM8 IL-6 Agonists:Atexakinalfa Interleukin6 Antibodies:ARGX-109 Clazakizumab Elsilimomab mAb1339 Olokizumab Sarilumab Siltuximab Sirukumab Tocilizumab Levilimab IL-7 Agonists:Interleukin7 IL-8 SeeCXCR1(IL-8Rα)andCXCR2(IL-8Rβ)hereinstead. IL-9 Agonists:Interleukin9 Antibodies:Enokizumab IL-10 Agonists:Ilodecakin Interleukin10(CSIF) IL-11 Agonists:Interleukin11(AGIF) Oprelvekin IL-12 Agonists:Edodekinalfa Interleukin12 Antibodies:Briakinumab Ustekinumab IL-13 Agonists:Binetrakin Cintredekinbesudotox Interleukin4 Interleukin13 Antibodies:Anrukinzumab Lebrikizumab Tralokinumab IL-15 Agonists:ALT-803 Interleukin15 IL-17 Agonists:Interleukin17(A,B,C,D,E(interleukin25),F) Antibodies:Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists:Iboctadekin Interleukin18 Interleukin37 Tadekinig Bindingproteins:IL18BP IL-20 Agonists:Interleukin19 Interleukin20 Interleukin24 Antibodies:Fletikumab(againstIL-20) IL-21 Agonists:Denenicokin Interleukin21 Antibodies:NNC0114-0005 NNC0114-0006 IL-22 Agonists:Interleukin22 Antibodies:Fezakinumab(againstIL-22) IL-23 Agonists:Interleukin23(SGRF) Antibodies:Brazikumab Briakinumab Guselkumab Risankizumab Tildrakizumab Ustekinumab IL-27 Agonists:Interleukin27(interleukin30) IL-28 Agonists:Interferonλ4(IFN-λ4) Interleukin28(A(IFN-λ2),B(IFN-λ3)) Interleukin-29(IFN-λ1) IL-31 Agonists:Interleukin31 IL1RL1 Agonists:Interleukin33 IL1RL2 Agonists:Interleukin36(α,β,γ) Interleukin38 Antagonists:IL-36RA OthersJAK Seehereinstead. Others Interleukin14(taxilinalpha,HMW-BCGF) Interleukin16(signalsthroughCD4) Interleukin24(signalsthroughIL-22Rα1/IL-20Rβheterodimer) Interleukin26(signalsthroughIL-20Rα/IL-10Rβheterodimer) Interleukin32 Interleukin34(signalsthroughM-CSFR/CSF1R) Interleukin35 Unsorted:Efavaleukinalfa Efineptakinalfa vteAstraZenecaProducts Acalabrutinib Anastrozole Andexanetalfa Anifrolumab Asfotasealfa Atenolol Benralizumab Bicalutamide Brompheniramine Budesonide Budesonide/formoterol Budesonide/glycopyrroniumbromide/formoterol Candesartan Dapagliflozin Disufentonsodium Durvalumab Eculizumab Esomeprazole Exenatide FluMist Fulvestrant Gefitinib Glycopyrroniumbromide/formoterol Goserelin Isosorbidemononitrate Metoprolol Motavizumab Olaparib Omeprazole Osimertinib Palivizumab Propofol Quetiapine Ravulizumab Roflumilast Rosuvastatin Roxadustat Savolitinib Saxagliptin Sebelipasealfa Selumetinib Sodiumzirconiumcyclosilicate Tamoxifen Ticagrelor Tixagevimab/cilgavimab Trastuzumabderuxtecan Vandetanib Vaxzevria Ximelagatran Zafirlukast Zolmitriptan Predecessorsandacquiredcompanies AstraAB AlexionPharmaceuticals CambridgeAntibodyTechnology MedImmune Zeneca People TomMcKillop LouisSchweitzer Category Commons Portal: Medicine Thismonoclonalantibody–relatedarticleisastub.YoucanhelpWikipediabyexpandingit.vte Thisdrugarticlerelatingtotherespiratorysystemisastub.YoucanhelpWikipediabyexpandingit.vte Retrievedfrom"https://en.wikipedia.org/w/index.php?title=Benralizumab&oldid=1093008898" Categories:AntiasthmaticdrugsMonoclonalantibodiesAstraZenecabrandsOrphandrugsMonoclonalantibodystubsRespiratorysystemdrugstubsHiddencategories:WebarchivetemplatewaybacklinksDrugswithnon-standardlegalstatusArticleswithchangedCASNoidentifierChemicalsthatdonothaveaChemSpiderIDassignedArticleswithchangedKEGGidentifierArticleswithoutEBIsourceArticleswithoutInChIsourceDrughasEMAlinkDrugboxeswhichcontainchangestoverifiedfieldsDrugboxeswhichcontainchangestowatchedfieldsDrugsthatareamonoclonalantibodyAllstubarticles Navigationmenu Personaltools NotloggedinTalkContributionsCreateaccountLogin Namespaces ArticleTalk English Views ReadEditViewhistory More Search Navigation MainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonate Contribute HelpLearntoeditCommunityportalRecentchangesUploadfile Tools WhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitem Print/export DownloadasPDFPrintableversion Languages العربيةDeutschفارسیFrançaisItaliano日本語ଓଡ଼ିଆPolski Editlinks