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方法：本研究使用糖尿病動物模式，5週齡BKS.CgDock7m +/+ Leprdb/J（db/db）小鼠購至國家實驗動物中心，實驗動物在適應一周後，隨機分配控制組（n=8）及運動組（n=8） ... 資料載入處理中... 跳到主要內容 臺灣博碩士論文加值系統 ::: 網站導覽| 首頁| 關於本站| 聯絡我們| 國圖首頁| 常見問題| 操作說明 English |FB專頁 |Mobile 免費會員 登入| 註冊 功能切換導覽列 (188.166.176.73)您好！臺灣時間：2022/04/0319:40 字體大小：       ::: 詳目顯示 recordfocus 第1筆/ 共1筆  /1頁 論文基本資料 摘要 外文摘要 目次 參考文獻 電子全文 紙本論文 論文連結 QRCode 本論文永久網址: 複製永久網址Twitter研究生:高浩瀚研究生(外文):Kao,Hao-Han論文名稱:有氧運動訓練調控能量代謝路徑對糖尿病db/db小鼠腎功能之影響論文名稱(外文):EffectsofaerobicexercisetrainingonregulationofrenalenergymetabolismbyactivatingAMPK-SIRT1pathwayindiabeticdb/dbmice指導教授:劉宏文指導教授(外文):Liu,Hung-Wen學位類別:碩士校院名稱:國立臺灣師範大學系所名稱:體育學系學門:教育學門學類:專業科目教育學類論文種類:學術論文論文出版年:2019畢業學年度:107語文別:中文論文頁數:45中文關鍵詞:腎病變、SIRT1、AMPKα、PGC1-α、發炎路徑外文關鍵詞:DiabeticNephropathy、SIRT1、AMPKα、PGC1-α、Inflammatorypathway相關次數: 被引用:0點閱:225評分:下載:31書目收藏:0 Sirtuin1（SIRT1）、AMP-activatedproteinkinase（AMPK）及peroxisomeproliferator-activatedreceptorgammacoactivator1-α（PGC1-α）為細胞內調節能量代謝的關鍵樞紐，AMPKα/SIRT1/PGC1α路經的受損伴隨粒線體失能是導致糖尿病腎臟病的機轉之一。

長期規律有氧運動可以改善早期糖尿病腎臟病變，避免病症繼續惡化。

然而，運動訓練經由AMPKα/SIRT1/PGC1α路徑改善糖尿病腎病變的機制，目前仍尚未釐清。

本研究假設為有氧運動訓練能上調腎臟中代謝路徑以及同時抑制發炎路徑的活化，達到改善早期糖尿病腎病變的效果。

方法：本研究使用糖尿病動物模式，5週齡BKS.CgDock7m+/+Leprdb/J（db/db）小鼠購至國家實驗動物中心，實驗動物在適應一周後，隨機分配控制組（n=8）及運動組（n=8）。

運動處方：跑步速度為5.2m/min，每天運動1小時，每週訓練5天，共進行8週。

運動訓練結束後將小鼠犧牲，以PAS染色法觀察腎臟組織型態，西方墨點法（Westernblotanalyses）分析能量代謝（AMPKα/SIRT1/PGC1-α）及發炎路徑（IκB-α/NF-κB）。

結果：八週有氧運動訓練後可以改善db/db小鼠腎絲球基質膜擴張，並增加SIRT1蛋白表現及AMPKα活性，同時抑制NF-κB磷酸化。

IκB-α、PGC1-α在運動組及控制組間無顯差異。

結論：本研究證實有氧運動訓練是透過活化能量代謝路徑和抑制發炎路徑來延緩糖尿病腎病變惡化。

TheAMPK-SIRT1-PGC-1αaxishasacrucialroleinregulatingtheenergymetabolismandmitochondrialfunction.DownregulationofAMPK/SIRT1/PGC1αpathwayisthemechanismleadingtodiabeticnephropathy.Thepurposeofthisstudywastodeterminewhetherexercisetrainingupregulatestheenergymetabolismpathwayandinhibitsinflammatorypathway,therebypreventingtheearlystagesofdiabeticnephropathy.Malediabetic（db/db）micewereusedinthepresentstudy.Attheageof5weeks,db/dbmiceweredividedintotwogroups:db/dbmice(n=8)withexercisetrainingfor8weeks(db/db+Ex)anddb/db(n=8)remainedsedentarythroughoutthestudy.Aerobicexercisetraining(5.2m/min,1h/day,and5days/weekforatotalof8weeks)wasstartedfrom5-week-old.Theresultsshowedthatdecreasedtheglomerularmatrixexpansionscore,increasedSIRT1proteinexpressionandAMPKαactivity,anddecreasedNF-κBphosphorylationwereobservedindb/db+Excomparedwithdb/dbmice.TherewerenosignificantchangesinIκB-αandPGC1-α.Therefore,thepresentstudyconfirmsthataerobicexercisetrainingalleviatestheprogressionofdiabeticnephropathybyactivatingAMPK-SIRT1pathwayandinhibitingNF-κBactivity. 中文摘要I英文摘要II謝誌III目次IV圖次VII第壹章緒論1第一節前言1第二節研究目的5第三節研究假設5第四節名詞操作性定義5第五節研究限制6第六節研究的價值7第貳章文獻探討8第一節糖尿病腎病變形成及致病機轉8第二節能量代謝失衡12第三節運動訓練預防糖尿病腎病變之分子機致制13第參章研究方法19第一節實驗動物19第二節實驗時間與地點19第三節實驗設計19第四節實驗方法與步驟20第五節資料分析24第肆章實驗結果26第伍章討論與結論33第陸章結論36引用文獻37 一、中文部分黃蘭菁、李貫廷、李育霖、楊偉勛、黃國晉（2013）。

2013年美國糖尿病學會臨床治療指引學會臨床治療指引摘要。

台北市醫師公會會刊，57（3），23-31蔡東華（2017）。

糖尿病腎病變。

中華民國糖尿病衛教學會13（1）。

21-24衛福部衛福部（2016）。

https：//www.hpa.gov.tw/Pages/List.aspx?nodeid=359李文欽、黃忠餘、張舜智、許君碩、蕭匡智、巫文平、李智威、田志宏（2013）。

腎絲球腎炎的致病機轉與治療原則。

腎臟與透析25（1），1-6。

莊武龍（2015）。

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