NOD scid Mice | Immunodeficient Model | Taconic Biosciences

NOD scid mice are immunodeficient mice with a diabetes-susceptible Non-Obese Diabetic (NOD) background for diabetes and obesity research. FindYourModel FindYourModel ModelSearch GEMs TaconicTransgenicModels™EmergingModelsCryopreservedModels StandardStrainsandStocks InbredOutbredHybrid/Congenic StandardImmunodeficients DietInducedMice HumanizedImmuneSystemMice huNOG-EXLModelPortfolioNOGPortfolio TherapeuticAreas&Solutions IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery 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IBDPortfolioMicrobiomePortfolioNeurosciencePortfolioOncologyImmuno-OncologytADMET™Portfolio 2022PricingGuide DesignYourModel DesignYourModel KnockoutMice Knock-inModels TransgenicMice KnockdownMice CRISPRGeneEditing ExpressMODEL®:EmbryonicStemCell ExpressMODEL®:RandomIntegrationTransgenic DrugDevelopment ModelGenerationSolutionsPublications MilestoneReports InquiryForm Taconic-CyagenAlliance BreedYourModel ColonyManagement AnimalBreedingandHusbandry AnimalModelHousingHealthMonitoringBreedingServicesBackcrossingandSpeedCongenics RederivationandRapidEXPANSION™ MouseandRatRederivationRapidEXPANSION™ CryopreservationandCryorecovery SpermandEmbryoCryopreservationCryorecoveryandFRapid®Expansion ProjectManagement ProjectManagementTeameTACONIC®Platform GenotypingandGeneticAnalysis GenotypingServicesTransgeneCharacterizationGeneExpressionAnalysisGeneticProfiling(SNPTesting) ColonyManagementPublications PrepareYourModel PrepareYourModel MicrobiomeSolutionsandGerm-FreeMice Germ-FreeMiceGerm-FreeDerivationsTruBIOME®FecalMicrobiotaTransplantationServiceFecalPelletsandMicrofloraDonorsMicrobiomeResources PreconditioningSolutions SpecialDietAdministrationAnimalAgingSurgicalModelsandServicesRodentID MurineBiospecimenCollection AnimalShippingProducts Contact searchsite searchsite eTACONIC TaconicFindyourmodelStandardStrainsandStocksNODscid NODscidSpontaneousMutant startanorder| printthispage| sharethispage Inquire CALL:888.822.6642 +4570230405(EUROPE) LiveproductionoftheNODscidmousehasceased.TaconicencouragescustomerstoconsiderswitchingtotheCIEANOGmouse®.NODBackground Model# Genotype Nomenclature NODSCNOD/MrkBomTac-Prkdcscid ModelDescription Thescidmutationhasbeentransferredontoadiabetes-susceptibleNon-ObeseDiabetic(NOD)backgroundThemultipledefectsinimmunityuniquetothismodelprovideanexcellentsystemforreconstitutionwithhumanhematopoieticcells,resultinginexceptionalmodelsforHIV-1researchandgenetherapyUsefulmodelforcancerresearchintoincreasedtumorincidence,particularlylymphomasandthymictumorsMaintainedinaspeciallyequippedIsolatedBarrierUnit™(IBU™)wherethefloraiscontinuouslymonitoredtoassuretheabsenceofspecificopportunisticbacteriaShortlifespan,8-9monthsduetolethalthymiclymphomasReducedNKcellactivityduetoNODbackgroundDoesnotdevelopdiabetesParalysisdoesseemtobeaphenotypeofNODscidmice,howeverinmeasuringthisphenotypeinourcoloniesitispresentinlessthan.5%GeneticBackground:NODBackgroundOrigin:TheNODscidSpontaneousmutantmodelwasdevelopedbytheFoxChaseCancerCenterbytransferringthescidmutationfromaC.B-17congenicbackgroundtoadiabetes-susceptiblenon-obesediabeticbackground.M&BA/S(nowTaconicEurope)receivedstockfromtheFoxChaseCancerCenterin1995.Themicewerederivedbyembryotransferin2002byTaconicUS.TheTaconicfoundationcolonywasatF?+14in2005.Genetics:RefertotheNOD(backgroundstrain)forinbredgeneticdataCoatColorLoci:TyrcColor:AlbinoSpecies:MouseAnimalDiet:NIH#31MRodentDiet GrowthChart Forsomeapplications,weightmaybecritical.Fororderswhereweightiscritical,pleaseplaceordersbyweight,notbyage.Taconiccanacceptordersbyweightforthismodel.Aminimum3gramspanisrequired.Allweightsareweightsattimeofpacking.Miceandratscanloseweightintransit.Ordersforspecificweightspanswillbeassessedanominalfee.Moredetailonweightorderpoliciesisavailable. n=200persexatRFhealthstandardfromallglobalcolonies.Datacollected2013-15. HighandLowrepresentmean+/-2standarddeviations.Basedonsamplesizethechartsaboverepresents~90%ofthepopulation. Allgrowthcurvesrepresentanimalshousedinourbarriers,atourstandarddensityandfedNIH31-Mdiet.Variationsatcustomerfacilitieswillalterexpectedgrowthcurves. Growthchartsareprovidedonlyasaguide,ifaspecificweightcriteriaisneededpleaseorderanimalsbyweight. Customizethischartbyclickingthelegendelements,thenexploredownloadoptionsbyhoveringyourcursoroverthedownarrowtotherightofthecharttitle. PhenotypicData Averagelittersize:6 Findyourmodel GEMsStandardStrainsandStocksInbredOutbredHybrid/CongenicStandardImmunodeficientsDietInducedMiceHumanizedImmuneSystemMiceTherapeuticAreas&Solutions2022PricingGuide 2022PricingGuideCreateyourcustomPricingGuide RelatedAnimalModels CIEANOGmouse®C.B-17scidICRscidNOD RelatedServices BreedYourModel RelatedPublications HepatitisBviruscoreantigenbindsandactivatesnaivehumanBcellsinvivo:studieswithahumanPBL-NOD/SCIDmousemodel.Humanneuralstemcelldifferentiationfollowingtransplantationintospinalcordinjuredmice:associationwithrecoveryoflocomotorfunction.SearchallNODscidpublications Close Welcome!Tellusalittleaboutyourself Hereweshowthechatwindow.