Captopril Test - Labcorp
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Captopril Test · Rationale: The administration of captopril, an angiotensin-converting enzyme inhibitor, produces an exaggerated rise in plasma renin activity ( ... Skiptomaincontent Alert: Forthesafetyofourpatientsandemployees,HurricaneIanmayaffectpatientservicecenterhoursinFlorida.Please reviewthelistofaffectedlocations forfurtherinformation. Dismiss / Home / CaptoprilTest CaptoprilTest Rationale: Theadministrationofcaptopril,anangiotensin-convertingenzymeinhibitor,producesanexaggeratedriseinplasmareninactivity(PRA)inpatientswithrenovascularhypertensionrelativetopatientswithessentialhypertension.1,2 PostcaptoprilPRAresultsmeetingthefollowingcriteriasuggestrenovascularhypertension.Allthreecriteriamustbemet.2 1.PRA>12ng/mL/hour 2.IncreaseinPRAofatleast10ng/mL/hourrelativetobaseline 3.IncreaseinPRA≥150%,orof400%ifthebaselinePRAis<3ng/mL/hour Protocol: Thepatientshouldbetakenoffantihypertensivemedicationsandhavenormalsaltintakeforseveraldayspriortotest.Thepatientshouldremainseatedthroughoutthetest.AnEDTAplasmasampleshouldbedrawnforreninactivity(PRA).Administer50mgcaptoprilorally.AsecondplasmasampleforPRAshouldbedrawnonehouraftercaptoprildosing.1 OrderableTest: ReninActivity,Plasma,TwoSpecimens(053686) (Baseline,one-hour) Note: Thecaptopriltesthastobeenshowntoproducefalse-positiveresultswhenusedtoscreenpatientswithlowriskofrenovascularhypertensionandhighbaselinePRAvalues.2 References 1.MullerFB,SealeyJE,CaseDB,etal.Thecaptopriltestforidentifyingrenovasculardiseaseinhypertensivepatients. AmJMed. 1986Apr;80(4):633-644. PubMed3515933 2.GerberLM,MannSJ,MüllerFB,etal.ResponsetothecaptopriltestIsdependentonbaselinereninprofile. JHypertens. 1994Feb;12(2):173-178. PubMed8021469 SecondaryNavigation Provider? PleaselogintoLabcorpLinkto payyourbill. ProviderLogin
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