Cryoprecipitate - Wikipedia

Cryoprecipitate, also called cryo for short, is a frozen blood product prepared from blood plasma. ... To create cryoprecipitate, fresh frozen plasma thawed to 1– ... Cryoprecipitate FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch Bloodproductpreparedfrombloodplasma CryoprecipitateClinicaldataOthernamesCryo,cryoprecipitatedantihaemophilicfactor,cryoprecipitatedAHFIdentifiersChemSpidernone Cryoprecipitate,alsocalledcryoforshort,isafrozenbloodproductpreparedfrombloodplasma.[1]Tocreatecryoprecipitate,freshfrozenplasmathawedto1–6 °Cisthencentrifugedandtheprecipitateiscollected.Theprecipitateisresuspendedinasmallamountofresidualplasma(generally10–15mL)andisthenre-frozenforstorage.Itisoftentransfusedtoadultsastwo5-unitpoolsinsteadofasasingleproduct.OneofthemostimportantconstituentsisfactorVIII(alsocalledantihaemophilicfactororAHF),whichiswhycryoprecipitateissometimescalledcryoprecipitatedantihaemophilicfactororcryoprecipitatedAHF.Inmanyclinicalcontexts,useofwholecryoprecipitatehasbeenreplacedwithuseofclottingfactorconcentratesmadetherefrom(whereavailable),butthewholeformisstillroutinelystockedbymany,ifnotmost,hospitalbloodbanks.Cryocanbestoredat−18 °Corcolderfor12monthsfromtheoriginalcollectiondate.[2]Afterthawing,singleunitsofcryo(orunitspooledusingasterilemethod)canbestoredat20–24 °Cforupto6hours.Ifunitsofcryoarepooledinanopensystem,theycanonlybeheldat20–24 °Cforupto4hours.[2]Presentlycryocannotbere-frozenforstorageafteritisthawedforuseifitisnottransfused. Cross-matching(compatibilitytesting)isnotnecessaryandallABOgroupsareacceptablefortransfusiontopeopleofallABOtypes.[1] Contents 1Medicaluses 2Adverseeffects 3Composition 4History 5References Medicaluses[edit] Medicalusesforgivingcryoprecipitateinclude:[3] Haemophilia–Usedforemergencybackupwhenfactorconcentratesarenotavailable. vonWillebranddisease–Notcurrentlyrecommendedunlesslastreserve.ddAVPisfirstline,followedbyfactorconcentrates. Hypofibrinogenaemia(lowfibrinogenlevels),ascanoccurwithmassivetransfusions Afibrinogenemia Bleedingfromexcessiveanticoagulation–Freshfrozenplasmacontainsmostofthecoagulationfactorsandisanalternativechoicewhenanticoagulationhastobereversedquickly. Massivehaemorrhage–RBCsandvolumeexpandersarepreferredtherapies. Disseminatedintravascularcoagulation Uremicbleedingtendency Reversingtpa(withaminocaproicacid) Adverseeffects[edit] Adverseeffectsreportedwiththeusageofcryoprecipitateincludehemolytictransfusionreactions,febrilenon-hemolyticreactions,allergicreactions(rangingfromurticariatoanaphylaxis),septicreactions,transfusionrelatedacutelunginjury,circulatoryoverload,transfusion-associatedgraft-versus-hostdisease,andpost-transfusionpurpura.[4] Composition[edit] Eachunit(around10to15mL)typicallyprovides:[5] Fibrinogen150–250 mgwithahalf-lifeof100–150hours FactorVIII80–150Uwithahalf-lifeof12hours FactorXIII50–75Uwithahalf-lifeof150–300hours. vonWillebrandfactor100–150Uwithahalf-lifeof24hours Cryoprecipitatealsocontainsfibronectin;howevertherearenoclearindicationsforfibronectinreplacement. USstandardsrequiremanufacturerstotestatleastfourunitseachmonth,andtheproductsmusthaveaminimumof150 mgormoreoffibrinogenand80IUoffactorVIII.[2][6]Individualproductsmayactuallyhavelessthantheseamountsaslongastheaverageremainsabovetheseminimums.Typicalvaluesforaunitaresubstantiallyhigher,andasidefrominfantsitisraretotransfusejustoneunit.[citationneeded] History[edit] WhilethemethodforthecreationofCryowasdiscoveredbyDr.JudithGrahamPoolfromStanfordUniversityin1964,[7]itwasinitiallyapprovedin1971bytheU.S.FoodandDrugAdministrationunderthenameCryoprecipitatedAHFfortheHoxworthBloodCenterUniversityofCincinnatiMedicalCenter.[8] References[edit] ^abTechnicalmanual.Fung,MarkK.,Grossman,BrendaJ.,Hillyer,ChristopherD.,Westhoff,ConnieM.,AmericanAssociationofBloodBanks.(18th ed.).Bethesda,Md.:AmericanAssociationofBloodBanks.2014.ISBN 978-1563958885.OCLC 881812415.{{citebook}}:CS1maint:others(link) ^abcCommittee.,AmericanAssociationofBloodBanks.StandardsProgram(2018).Standardsforbloodbanksandtransfusionservices(31st ed.).Bethesda,Maryland.ISBN 978-1563959585.OCLC 1022963387. ^ErberWN,PerryDJ(2006)."Plasmaandplasmaproductsinthetreatmentofmassivehaemorrhage".BestPractResClinHaematol.19(1):97–112.doi:10.1016/j.beha.2005.01.026.PMID 16377544. ^"CRYO(cryoprecipitate)AdverseEffects".Medscape. ^"CRYO(cryoprecipitate)pharmacology".Medscape. ^ "CircularofInformationFortheUseofHumanBloodandBloodComponents"(PDF).FoodandDrugAdministration.Archivedfromtheoriginal(PDF)on2008-02-27.Retrieved2008-02-28. ^Pool,JudithG.;Hershgold,EdwabdJ.;Pappenhagen,AlbertR.(July1964)."High-potencyAntihæmophilicFactorConcentratepreparedfromCryoglobulinPrecipitate".Nature.203(4942):312.Bibcode:1964Natur.203..312P.doi:10.1038/203312a0.ISSN 0028-0836.PMID 14201780.S2CID 4243913. ^"AlphabeticalListofLicensedEstablishmentsIncludingProductApprovalDatesasof30-APR-2019".FDA. vteBloodtransfusionandtransfusionmedicineBloodproducts Wholeblood Platelets Platelettransfusion Redbloodcells Plasma Freshfrozenplasma PF24 Cryoprecipitate Cryosupernatant Whitebloodcells Granulocytetransfusion Bloodsubstitutes Generalconcepts Bloodbank Blooddonation Bloodmanagement Methods Apheresis(plasmapheresis,plateletpheresis,leukapheresis) Exchangetransfusion Intraoperativebloodsalvage Tests Bloodcompatibilitytesting Cross-matching Coombstest Kleihauer–Betketest InternationalSocietyofBloodTransfusion ISBT128 Transfusionreactionsandadverseeffects Transfusionhemosiderosis Transfusionrelatedacutelunginjury Transfusionassociatedcirculatoryoverload Transfusion-associatedgraftversushostdisease Febrilenon-hemolytictransfusionreaction Hemolyticreaction acute delayed Serumsickness Transfusiontransmittedinfection Bloodgroupsystems Bloodtypes ABO Secretorstatus Augustine CD59 Chido-Rodgers Colton Cromer Diego Dombrock Duffy Er FORS Gerbich GIL GLOB Hh Ii Indian JR JMH KANNO Kell(Xk) Kidd Knops Lan Lewis Lutheran LW MNS OK P Raph RhandRHAG Scianna Sid T-Tn Vel Xg Yt Other vteIntravenoustherapyInfusedsubstancesBlood-basedproduct Wholeblood PF24/Freshfrozenplasma(Cryosupernatant+Cryoprecipitate) Bloodsubstitute Hemoglobin-based Volumeexpander LactatedRinger's Normalsaline Sugarsolution Buffers LactatedRinger's,Sodiumbicarbonate Medications Intravenousimmunoglobulin Parenteralnutrition Sugar Other Druginjection Ascorbicacid Accesspoints Peripheralvenouscatheter Peripherallyinsertedcentralcatheter(Seldingertechnique) Centralvenouscatheter Otherequipment Infusionpump CVC SLC MLC PICC Implantablecatheters Ports Thermodilutioncatheters Hemodialysiscatheters Specificrisks Airembolism Extravasation Seealso Needleandsyringeprogrammes Supervisedinjectionsite Retrievedfrom"https://en.wikipedia.org/w/index.php?title=Cryoprecipitate&oldid=1077544118" Categories:BloodproductsTransfusionmedicineHiddencategories:CS1maint:othersArticleswithshortdescriptionShortdescriptionmatchesWikidataChemicalsthatdonothaveaChemSpiderIDassignedInfoboxdrugarticleswithoutastructureimageChemicalarticleswithoutCASregistrynumberArticleswithoutEBIsourceChemicalpageswithoutDrugBankidentifierArticleswithoutKEGGsourceArticleswithoutInChIsourceArticleswithoutUNIIsourceDrugsmissinganATCcodeDrugswithnolegalstatusArticlescontainingunverifiedchemicalinfoboxesAllarticleswithunsourcedstatementsArticleswithunsourcedstatementsfromDecember2021 Navigationmenu Personaltools NotloggedinTalkContributionsCreateaccountLogin Namespaces ArticleTalk English Views ReadEditViewhistory More Search Navigation MainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonate Contribute HelpLearntoeditCommunityportalRecentchangesUploadfile Tools WhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitem Print/export DownloadasPDFPrintableversion Languages FrançaisItalianoNederlandsPolskiPortuguês Editlinks