NOD miceNOG miceMultiple defects in innate and adaptive immunologic function in NOD/LtSz-scid miceNSG SGM3

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Nomenclature, NOD.Cg-Prkdc scid ll2rg tm1Wjl /SzJ/Arc. Product code, NSG. JAX stock number, 005557. Strain Description, Congenic,Spontaneous Mutation ...   Home›AnimalsModels›InducedMutantMice›NSG NSG HealthReport Nomenclature NOD.Cg-Prkdcscid ll2rgtm1Wjl/SzJ/Arc Productcode NSG JAXstocknumber 005557 StrainDescription Congenic,SpontaneousMutation,TargetedMutation CoatColour Albino(A/A Tyrc/Tyrc) MHCHaplotype H2Kg7 ThisstrainisonlyavailableforAustralianandNewZealandresearchers NSGmicecombinethefeaturesoftheNOD/ShiLtJbackground,theseverecombinedimmunedeficiencymutation(scid)andIL2receptorgammachaindeficiency.Asaresult,theseNSGmicelackmatureTcells,Bcells,orfunctionalNKcells,andaredeficientincytokinesignaling,leadingtobetterengraftmentofhumanhematopoieticstemcellsandperipheral-bloodmononuclearcellsthananyotherpublishedmousestrain.Recentpublicationshavedemonstratedthisstrain’soutstandingutilityinthestudiesofislettransplantation,hematopoieticstemcellsandcancerstemcells. Likeitsparentalstrain,NOD/ShiLtJ(StockNo. 001976),NSGmiceexhibitaprogressivehearinglossthatisalreadyseverebythreemonthsofage. HousedinisolatorsattheARC. DuetotheirlevelofimmunodeficiencyNSGmiceneedtobemaintainedina‘maximumbarrier’.A descriptionofmaximumbarrierconditionsandpractices isavailableontheJaxwebsite. Furtherdetailedinformationisalsoavailableat: http://jaxmice.jax.org/strain/005557.html ThesemicearesoldsubjecttoTheJacksonLaboratory’sConditionsofUseandalsotheAustralianPatentNumber(2004268530).Informationregardingconditionsofuseisavailableat: http://jaxmice.jax.org/cou/index.html.     ©2022 AnimalResourcesCentre PrivacyPolicy

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