益氣聰明湯對Aβ(1-40)誘發認知障礙之治療與保護作用是經由 ...
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關鍵字: 益氣聰明湯;Yi-Chi-Tsung-Ming-Tang;乙型類澱粉蛋白;阿滋海默症;乙醯膽鹼;N-甲基-D-天冬氨酸受器;β-amyloid;Alzheimer's disease;acetylcholine;NMDARs.
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標題: 益氣聰明湯對Aβ(1-40)誘發認知障礙之治療與保護作用是經由增加乙醯膽鹼與降低Aβ之表現TherapeuticandprotectiveeffectsofYi-Chi-Tsung-Ming-Tangonthecognitiondeficitsinducedbyβ-amyloidpeptide(1-40)viaincreasingacetylcholineanddecreasingβ-amyloidexpression
作者: 葉宗勳Yeh,Chung-hsin
關鍵字: 益氣聰明湯;Yi-Chi-Tsung-Ming-Tang;乙型類澱粉蛋白;阿滋海默症;乙醯膽鹼;N-甲基-D-天冬氨酸受器;β-amyloid;Alzheimer’sdisease;acetylcholine;NMDARs
出版社: 生命科學系所
引用: References
Adlard,P.A.,James,S.A.,Bush,A.I.,andMasters,C.L.(2009).beta-AMYLOIDASAMOLECULARTHERAPEUTICTARGETINALZHEIMER''SDISEASE.DrugToday45,293-304.
Ahn,J.,Um,M.,Choi,W.,Kim,S.,andHa,T.(2006).ProtectiveeffectsofGlycyrrhizauralensisFisch.onthecognitivedeficitscausedbybeta-amyloidpeptide25-35inyoungmice.Biogerontology7,239-247.
Akhondzadeh,S.,Noroozian,M.,Mohammadi,M.,Ohadinia,S.,Jamshidi,A.H.,andKhani,M.(2003).SalviaofficinalisextractinthetreatmentofpatientswithmildtomoderateAlzheimer''sdisease:adoubleblind,randomizedandplacebo-controlledtrial.JClinPharmTher28,53-59.
AlzheimersAssoc(2012).2012Alzheimer''sdiseasefactsandfigures.Alzheimers&Dementia8,131-168.
Andersson,O.,Stenqvist,A.,Attersand,A.,andvonEuler,G.(2001).Nucleotidesequence,genomicorganization,andchromosomallocalizationofgenesencodingthehumanNMDAreceptorsubunitsNR3AandNR3B.Genomics78,178-184.
Bachevalier,J.,andMeunier,M.(1996).Cerebralischemia:arethememorydeficitsassociatedwithhippocampalcellloss?Hippocampus6,553-560.
Barak,S.,andWeiner,I.(2010).Differentialroleofmuscarinictransmissionwithintheentorhinalcortexandbasolateralamygdalaintheprocessingofirrelevantstimuli.Neuropsychopharmacology35,1073-1082.
Barnes,C.A.,Meltzer,J.,Houston,F.,Orr,G.,McGann,K.,andWenk,G.L.(2000).Chronictreatmentofoldratswithdonepezilorgalantamine:effectsonmemory,hippocampalplasticityandnicotinicreceptors.Neuroscience99,17-23.
Bartus,R.T.,Dean,R.L.,3rd,Beer,B.,andLippa,A.S.(1982).Thecholinergichypothesisofgeriatricmemorydysfunction.Science217,408-414.
Bartus,R.T.,Dean,R.L.,3rd,Sherman,K.A.,Friedman,E.,andBeer,B.(1981).Profoundeffectsofcombiningcholineandpiracetamonmemoryenhancementandcholinergicfunctioninagedrats.NeurobiolAging2,105-111.
Bastianetto,S.,Ramassamy,C.,Dore,S.,Christen,Y.,Poirier,J.,andQuirion,R.(2000).TheGinkgobilobaextract(EGb761)protectshippocampalneuronsagainstcelldeathinducedbybeta-amyloid.EurJNeurosci12,1882-1890.
Blennow,K.,deLeon,M.J.,andZetterberg,H.(2006).Alzheimer''sdisease.Lancet368,387-403.
Boada-Rovira,M.,Brodaty,H.,Cras,P.,Baloyannis,S.,Emre,M.,Zhang,R.,andBahra,R.(2004).EfficacyandsafetyofdonepezilinpatientswithAlzheimer''sdisease:resultsofaglobal,multinational,clinicalexperiencestudy.DrugsAging21,43-53.
Boyd-Kimball,D.,Sultana,R.,Poon,H.F.,Lynn,B.C.,Casamenti,F.,Pepeu,G.,Klein,J.B.,andButterfield,D.A.(2005).Proteomicidentificationofproteinsspecificallyoxidizedbyintracerebralinjectionofamyloidbeta-peptide(1-42)intoratbrain:implicationsforAlzheimer''sdisease.Neuroscience132,313-324.
Breitner,J.C.(1996).Theroleofanti-inflammatorydrugsinthepreventionandtreatmentofAlzheimer''sdisease.AnnuRevMed47,401-411.
Butterfield,D.,Castegna,A.,Pocernich,C.,Drake,J.,Scapagnini,G.,andCalabrese,V.(2002).NutritionalapproachestocombatoxidativestressinAlzheimer''sdisease.JNutrBiochem13,444.
Butterfield,D.A.,Drake,J.,Pocernich,C.,andCastegna,A.(2001).EvidenceofoxidativedamageinAlzheimer''sdiseasebrain:centralroleforamyloidbeta-peptide.TrendsMolMed7,548-554.
Butterfield,D.A.,andLauderback,C.M.(2002).LipidperoxidationandproteinoxidationinAlzheimer''sdiseasebrain:potentialcausesandconsequencesinvolvingamyloidbeta-peptide-associatedfreeradicaloxidativestress.FreeRadicBiolMed32,1050-1060.
Butterfield,D.A.,andPocernich,C.B.(2003).TheglutamatergicsystemandAlzheimer''sdisease:therapeuticimplications.CNSDrugs17,641-652.
Butterfield,D.A.,Reed,T.,Newman,S.F.,andSultana,R.(2007).Rolesofamyloidbeta-peptide-associatedoxidativestressandbrainproteinmodificationsinthepathogenesisofAlzheimer''sdiseaseandmildcognitiveimpairment.FreeRadicBiolMed43,658-677.
Canevari,L.,Clark,J.B.,andBates,T.E.(1999).beta-Amyloidfragment25-35selectivelydecreasescomplexIVactivityinisolatedmitochondria.FEBSLett457,131-134.
Cantarella,G.,Uberti,D.,Carsana,T.,Lombardo,G.,Bernardini,R.,andMemo,M.(2003).NeutralizationofTRAILdeathpathwayprotectshumanneuronalcelllinefrombeta-amyloidtoxicity.CellDeathDiffer10,134-141.
CaoXZ,Z.L.,ShenYE,ZhouSS,JiangGH.(2006).EffectofgalantaminoncognitivefunctionofAlzheimer''sdiseaseinratsmediatedbyNMDAreceptors.JApopNervDis23:678-80.
Cappai,R.,andBarnham,K.J.(2008).DelineatingthemechanismofAlzheimer''sdiseaseAbetapeptideneurotoxicity.NeurochemRes33,526-532.
Chang,R.C.,andSo,K.F.(2008).Useofanti-agingherbalmedicine,Lyciumbarbarum,againstaging-associateddiseases.Whatdoweknowsofar?CellMolNeurobiol28,643-652.
Chen,K.C.,Liao,C.W.,Cheng,F.P.,Chou,C.C.,Chang,S.C.,Wu,J.H.,Zen,J.M.,Chen,Y.T.,andLiao,J.W.(2009).Evaluationofsubchronictoxicityofpetfoodcontaminatedwithmelamineandcyanuricacidinrats.ToxicolPathol37,959-968.
Chen,Q.S.,Wei,W.Z.,Shimahara,T.,andXie,C.W.(2002).Alzheimeramyloidbeta-peptideinhibitsthelatephaseoflong-termpotentiationthroughcalcineurin-dependentmechanismsinthehippocampaldentategyrus.NeurobiologyofLearningandMemory77,354-371.
Cheng,H.Y.,Hsieh,M.T.,Wu,C.R.,Tsai,F.H.,Lu,T.C.,Hsieh,C.C.,Li,W.C.,Lin,Y.T.,andPeng,W.H.(2008).Schizandrinprotectsprimaryculturesofratcorticalcellsfromglutamate-inducedexcitotoxicity.JPharmacolSci107,21-31.
Chiang,P.K.,Lam,M.A.,andLuo,Y.(2008).ThemanyfacesofamyloidbetainAlzheimer''sdisease.CurrMolMed8,580-584.
Chohan,M.O.,andIqbal,K.(2006).Fromtautotoxicity:emergingrolesofNMDAreceptorinAlzheimer''sdisease.JAlzheimersDis10,81-87.
Christen,Y.(2000).OxidativestressandAlzheimerdisease.AmJClinNutr71,621S-629S.
Chung,I.W.,Moore,N.A.,Oh,W.K.,O''Neill,M.F.,Ahn,J.S.,Park,J.B.,Kang,U.G.,andKim,Y.S.(2002).Behaviouralpharmacologyofpolygalasaponinsindicatespotentialantipsychoticefficacy.PharmacolBiochemBehav71,191-195.
Chung,Y.K.,Heo,H.J.,Kim,E.K.,Kim,H.K.,Huh,T.L.,Lim,Y.,Kim,S.K.,andShin,D.H.(2001).InhibitoryeffectofursolicacidpurifiedfromOriganummajoranaLontheacetylcholinesterase.MolCells11,137-143.
Conway,K.A.,Baxter,E.W.,Felsenstein,K.M.,andReitz,A.B.(2003).Emergingbeta-amyloidtherapiesforthetreatmentofAlzheimer''sdisease.CurrPharmDes9,427-447.
Czech,C.,Masters,C.,andBeyreuther,K.(1994).Alzheimer''sdiseaseandtransgenicmice.JNeuralTransmSuppl44,219-230.
David,R.,Zeitzer,J.,Friedman,L.,Noda,A.,O''Hara,R.,Robert,P.,andYesavage,J.A.(2010).Non-pharmacologicmanagementofsleepdisturbanceinAlzheimer''sdisease.JNutrHealthAging14,203-206.
Decker,M.W.,andMcGaugh,J.L.(1991).Theroleofinteractionsbetweenthecholinergicsystemandotherneuromodulatorysystemsinlearningandmemory.Synapse7,151-168.
Delrieu,J.,Ousset,P.J.,Caillaud,C.,andVellas,B.(2012).''ClinicaltrialsinAlzheimer''sdisease'':immunotherapyapproaches.JNeurochem120Suppl1,186-193.
Dewachter,I.,Filipkowski,R.K.,Priller,C.,Ris,L.,Neyton,J.,Croes,S.,Terwel,D.,Gysemans,M.,Devijver,H.,Borghgraef,P.,etal.(2009).DeregulationofNMDA-receptorfunctionanddown-streamsignalinginAPP[V717I]transgenicmice.NeurobiolAging30,241-256.
Dingledine,R.,Borges,K.,Bowie,D.,andTraynelis,S.F.(1999).Theglutamatereceptorionchannels.PharmacolRev51,7-61.
Duyckaerts,C.,Delatour,B.,andPotier,M.C.(2009).ClassificationandbasicpathologyofAlzheimerdisease.ActaNeuropathologica118,5-36.
Eckert,A.,Hauptmann,S.,Scherping,I.,Meinhardt,J.,Rhein,V.,Drose,S.,Brandt,U.,Fandrich,M.,Muller,W.E.,andGotz,J.(2008).Oligomericandfibrillarspeciesofbeta-amyloid(Abeta42)bothimpairmitochondrialfunctioninP301Ltautransgenicmice.JMolMed86,1255-1267.
Ezoulin,M.J.,Ombetta,J.E.,Dutertre-Catella,H.,Warnet,J.M.,andMassicot,F.(2008).AntioxidativepropertiesofgalantamineonneuronaldamageinducedbyhydrogenperoxideinSK-N-SHcells.Neurotoxicology29,270-277.
Fang,F.,Chen,X.,Huang,T.,Lue,L.F.,Luddy,J.S.,andYan,S.S.(2012).Multi-facedneuroprotectiveeffectsofGinsenosideRg1inanAlzheimermousemodel.BiochimBiophysActa1822,286-292.
Ferri,C.P.,Prince,M.,Brayne,C.,Brodaty,H.,Fratiglioni,L.,Ganguli,M.,Hall,K.,Hasegawa,K.,Hendrie,H.,Huang,Y.,etal.(2005).Globalprevalenceofdementia:aDelphiconsensusstudy.Lancet366,2112-2117.
Flood,J.F.,Morley,J.E.,andRoberts,E.(1991).AmnesticeffectsinmiceoffoursyntheticpeptideshomologoustoamyloidbetaproteinfrompatientswithAlzheimerdisease.ProcNatlAcadSciUSA88,3363-3366.
Fujiwara,H.,Iwasaki,K.,Furukawa,K.,Seki,T.,He,M.,Maruyama,M.,Tomita,N.,Kudo,Y.,Higuchi,M.,Saido,T.C.,etal.(2006).Uncariarhynchophylla,aChinesemedicinalherb,haspotentantiaggregationeffectsonAlzheimer''sbeta-amyloidproteins.JNeurosciRes84,427-433.
Furey,M.L.,Pietrini,P.,Alexander,G.E.,Schapiro,M.B.,andHorwitz,B.(2000).Cholinergicenhancementimprovesperformanceonworkingmemorybymodulatingthefunctionalactivityindistinctbrainregions:apositronemissiontomographyregionalcerebralbloodflowstudyinhealthyhumans.BrainResBull51,213-218.
Furey,M.L.,Pietrini,P.,Haxby,J.V.,andDrevets,W.C.(2008).Selectiveeffectsofcholinergicmodulationontaskperformanceduringselectiveattention.Neuropsychopharmacology33,913-923.
Gallagher,M.(2011).Evaluatingaprotocoltotrainhospicestaffinadministeringindividualizedmusic.IntJPalliatNurs17,195-201.
Gertz,H.J.,andKiefer,M.(2004).ReviewaboutGinkgobilobaspecialextractEGb761(Ginkgo).CurrPharmDes10,261-264.
Gilman,S.,Koller,M.,Black,R.S.,Jenkins,L.,Griffith,S.G.,Fox,N.C.,Eisner,L.,Kirby,L.,Rovira,M.B.,Forette,F.,etal.(2005).ClinicaleffectsofAbetaimmunization(AN1792)inpatientswithADinaninterruptedtrial.Neurology64,1553-1562.
Glenner,G.G.(1989).AmyloidbetaproteinandthebasisforAlzheimer''sdisease.ProgClinBiolRes317,857-868.
Graef,S.,Schonknecht,P.,Sabri,O.,andHegerl,U.(2011).Cholinergicreceptorsubtypesandtheirroleincognition,emotion,andvigilancecontrol:anoverviewofpreclinicalandclinicalfindings.Psychopharmacology(Berl)215,205-229.
Greenamyre,J.T.(1986).Theroleofglutamateinneurotransmissionandinneurologicdisease.ArchNeurol43,1058-1063.
Gu,Q.(2003).Contributionofacetylcholinetovisualcortexplasticity.NeurobiologyofLearningandMemory80,291-301.
Haass,C.,Schlossmacher,M.G.,Hung,A.Y.,Vigo-Pelfrey,C.,Mellon,A.,Ostaszewski,B.L.,Lieberburg,I.,Koo,E.H.,Schenk,D.,Teplow,D.B.,etal.(1992).Amyloidbeta-peptideisproducedbyculturedcellsduringnormalmetabolism.Nature359,322-325.
Haass,C.,andSelkoe,D.J.(2007).Solubleproteinoligomersinneurodegeneration:lessonsfromtheAlzheimer''samyloidbeta-peptide.NatRevMolCellBiol8,101-112.
Habicht,G.,Haupt,C.,Friedrich,R.P.,Hortschansky,P.,Sachse,C.,Meinhardt,J.,Wieligmann,K.,Gellermann,G.P.,Brodhun,M.,Gotz,J.,etal.(2007).DirectedselectionofaconformationalantibodydomainthatpreventsmatureamyloidfibrilformationbystabilizingAbetaprotofibrils.PNatlAcadSciUSA104,19232-19237.
Hamaguchi,T.,Ono,K.,Murase,A.,andYamada,M.(2009).PhenoliccompoundspreventAlzheimer''spathologythroughdifferenteffectsontheamyloid-betaaggregationpathway.AmJPathol175,2557-2565.
Hardy,J.,andSelkoe,D.J.(2002).TheamyloidhypothesisofAlzheimer''sdisease:progressandproblemsontheroadtotherapeutics.Science297,353-356.
Harkany,T.,Abraham,I.,Timmerman,W.,Laskay,G.,Toth,B.,Sasvari,M.,Konya,C.,Sebens,J.B.,Korf,J.,Nyakas,C.,etal.(2000).beta-amyloidneurotoxicityismediatedbyaglutamate-triggeredexcitotoxiccascadeinratnucleusbasalis.EurJNeurosci12,2735-2745.
Hattori,H.,Hattori,C.,Hokao,C.,Mizushima,K.,andMase,T.(2011).ControlledstudyonthecognitiveandpsychologicaleffectofcoloringanddrawinginmildAlzheimer''sdiseasepatients.GeriatrGerontolInt11,431-437.
Hernandez,S.S.,Coelho,F.G.,Gobbi,S.,andStella,F.(2010).[Effectsofphysicalactivityoncognitivefunctions,balanceandriskoffallsinelderlypatientswithAlzheimer''sdementia].RevBrasFisioter14,68-74.
Hirtz,D.,Thurman,D.J.,Gwinn-Hardy,K.,Mohamed,M.,Chaudhuri,A.R.,andZalutsky,R.(2007).Howcommonarethe"common"neurologicdisorders?Neurology68,326-337.
Ho,Y.S.,So,K.F.,andChang,R.C.(2010).Anti-agingherbalmedicine--howandwhycantheybeusedinaging-associatedneurodegenerativediseases?AgeingResRev9,354-362.
Ho,Y.S.,Yang,X.F.,Yu,M.S.,So,K.F.,Yuen,W.H.,Chang,R.C.C.(2009).Wolfberrypolysaccharideprotectsprimarycorticalneuronsfromhomocysteine-inducedneurotoxicity.NeurodegenerativeDiseases6(Suppl.1):2186.
Hoi,C.P.,Ho,Y.P.,Baum,L.,andChow,A.H.(2010).Neuroprotectiveeffectofhonokiolandmagnolol,compoundsfromMagnoliaofficinalis,onbeta-amyloid-inducedtoxicityinPC12cells.PhytotherRes24,1538-1542.
Hsieh,C.L.,Cheng,C.Y.,Tsai,T.H.,Lin,I.H.,Liu,C.H.,Chiang,S.Y.,Lin,J.G.,Lao,C.J.,andTang,N.Y.(2006).Paeonolreducedcerebralinfarctioninvolvingthesuperoxideanionandmicrogliaactivationinischemia-reperfusioninjuredrats.JEthnopharmacol106,208-215.
Hsieh,M.T.,Peng,W.H.,Wu,C.R.,Ng,K.Y.,Cheng,C.L.,andXu,H.X.(2010).Reviewonexperimentalresearchofherbalmedicineswithanti-amnesicactivity.PlantaMed76,203-217.
Hsieh,M.T.,Wu,C.R.,Wang,W.H.,andLin,L.W.(2001).TheamelioratingeffectofthewaterlayerofFructusSchisandraeoncycloheximide-inducedamnesiainrats:interactionwithdrugsactingatneurotransmitterreceptors.PharmacolRes43,17-22.
Hu,W.,Gray,N.W.,andBrimijoin,S.(2003).Amyloid-betaincreasesacetylcholinesteraseexpressioninneuroblastomacellsbyreducingenzymedegradation.JNeurochem86,470-478.
Huang,H.C.,andJiang,Z.F.(2009).Accumulatedamyloid-betapeptideandhyperphosphorylatedtauprotein:relationshipandlinksinAlzheimer''sdisease.JAlzheimersDis16,15-27.
Imahori,K.(2010).ThebiochemicalstudyontheetiologyofAlzheimer''sdisease.ProcJpnAcadSerBPhysBiolSci86,54-61.
Isik,A.T.,Celik,T.,Ulusoy,G.,Ongoru,O.,Elibol,B.,Doruk,H.,Bozoglu,E.,Kayir,H.,Mas,M.R.,andAkman,S.(2009).Curcuminamelioratesimpairedinsulin/IGFsignallingandmemorydeficitinastreptozotocin-treatedratmodel.Age(Dordr)31,39-49.
Itoh,A.,Akaike,T.,Sokabe,M.,Nitta,A.,Iida,R.,Olariu,A.,Yamada,K.,andNabeshima,T.(1999).Impairmentsoflong-termpotentiationinhippocampalslicesofbeta-amyloid-infusedrats.EurJPharmacol382,167-175.
Itoh,A.,Nitta,A.,Nadai,M.,Nishimura,K.,Hirose,M.,Hasegawa,T.,andNabeshima,T.(1996).Dysfunctionofcholinergicanddopaminergicneuronalsystemsinbeta-amyloidprotein--infusedrats.JNeurochem66,1113-1117.
Jacobsen,J.S.,Wu,C.C.,Redwine,J.M.,Comery,T.A.,Arias,R.,Bowlby,M.,Martone,R.,Morrison,J.H.,Pangalos,M.N.,Reinhart,P.H.,etal.(2006).Early-onsetbehavioralandsynapticdeficitsinamousemodelofAlzheimer''sdisease.ProcNatlAcadSciUSA103,5161-5166.
Jazi,R.,Lalonde,R.,Qian,S.,andStrazielle,C.(2009).RegionalbrainevaluationofacetylcholinesteraseactivityinPS1/A246Etransgenicmice.NeurosciRes63,106-114.
Jeon,S.,Hur,J.,Jeong,H.J.,Koo,B.S.,andPak,S.C.(2011).SuHeXiangWanessentialoilalleviatesamyloidbetainducedmemoryimpairmentthroughinhibitionoftauproteinphosphorylationinmice.AmJChinMed39,917-932.
Jhoo,J.H.,Kim,H.C.,Nabeshima,T.,Yamada,K.,Shin,E.J.,Jhoo,W.K.,Kim,W.,Kang,K.S.,Jo,S.A.,andWoo,J.I.(2004).beta-amyloid(1-42)-inducedlearningandmemorydeficitsinmice:involvementofoxidativeburdensinthehippocampusandcerebralcortex.BehaviouralBrainResearch155,185-196.
Jia,H.,Jiang,Y.,Ruan,Y.,Zhang,Y.,Ma,X.,Zhang,J.,Beyreuther,K.,Tu,P.,andZhang,D.(2004).TenuigenintreatmentdecreasessecretionoftheAlzheimer''sdiseaseamyloidbeta-proteininculturedcells.NeurosciLett367,123-128.
Jimbo,D.,Kimura,Y.,Taniguchi,M.,Inoue,M.,andUrakami,K.(2009).EffectofaromatherapyonpatientswithAlzheimer''sdisease.Psychogeriatrics9,173-179.
Jones,S.,Sudweeks,S.,andYakel,J.L.(1999).Nicotinicreceptorsinthebrain:correlatingphysiologywithfunction.TrendsNeurosci22,555-561.
Kalaria,R.N.,Maestre,G.E.,Arizaga,R.,Friedland,R.P.,Galasko,D.,Hall,K.,Luchsinger,J.A.,Ogunniyi,A.,Perry,E.K.,Potocnik,F.,etal.(2008).Alzheimer''sdiseaseandvasculardementiaindevelopingcountries:prevalence,management,andriskfactors.LancetNeurol7,812-826.
Kar,S.,Issa,A.M.,Seto,D.,Auld,D.S.,Collier,B.,andQuirion,R.(1998).Amyloidbeta-peptideinhibitshigh-affinitycholineuptakeandacetylcholinereleaseinrathippocampalslices.JNeurochem70,2179-2187.
Kasper,S.,andSchubert,H.(2009).[GinkgobilobaextractEGb761inthetreatmentofdementia:evidenceofefficacyandtolerability].FortschrNeurolPsychiatr77,494-506.
Kennedy,M.B.(2000).Signal-processingmachinesatthepostsynapticdensity.Science290,750-754.
Kerer,M.,Marksteiner,J.,Hinterhuber,H.,Mazzola,G.,Steinberg,R.,andWeiss,E.M.(2009).[Dementiaandmusic].Neuropsychiatr23,4-14.
Klafki,H.W.,Staufenbiel,M.,Kornhuber,J.,andWiltfang,J.(2006).TherapeuticapproachestoAlzheimer''sdisease.Brain129,2840-2855.
Klinkenberg,I.,Sambeth,A.,andBlokland,A.(2011).Acetylcholineandattention.BehavBrainRes221,430-442.
Kohr,G.,andSeeburg,P.H.(1996).Subtype-specificregulationofrecombinantNMDAreceptor-channelsbyproteintyrosinekinasesofthesrcfamily.JPhysiol492(Pt2),445-452.
Kowall,N.W.,Beal,M.F.,Busciglio,J.,Duffy,L.K.,andYankner,B.A.(1991).AninvivomodelfortheneurodegenerativeeffectsofbetaamyloidandprotectionbysubstanceP.ProcNatlAcadSciUSA88,7247-7251.
Kulkarni,S.K.,andDhir,A.(2010).Berberine:aplantalkaloidwiththerapeuticpotentialforcentralnervoussystemdisorders.PhytotherRes24,317-324.
Kurz,A.,andVanBaelen,B.(2004).Ginkgobilobacomparedwithcholinesteraseinhibitorsinthetreatmentofdementia:areviewbasedonmeta-analysesbythecochranecollaboration.DementGeriatrCognDisord18,217-226.
Lacor,P.N.,Buniel,M.C.,Furlow,P.W.,Clemente,A.S.,Velasco,P.T.,Wood,M.,Viola,K.L.,andKlein,W.L.(2007).Abetaoligomer-inducedaberrationsinsynapsecomposition,shape,anddensityprovideamolecularbasisforlossofconnectivityinAlzheimer''sdisease.JNeurosci27,796-807.
Lahiri,D.K.,Ghosh,C.,andGe,Y.W.(2003).Aproximalgenepromoterregionforthebeta-amyloidprecursorproteinprovidesalinkbetweendevelopment,apoptosis,andAlzheimer''sdisease.AnnNYAcadSci1010,643-647.
Laube,B.,Kuhse,J.,andBetz,H.(1998).EvidenceforatetramericstructureofrecombinantNMDAreceptors.JNeurosci18,2954-2961.
Lauren,J.,Gimbel,D.A.,Nygaard,H.B.,Gilbert,J.W.,andStrittmatter,S.M.(2009).Cellularprionproteinmediatesimpairmentofsynapticplasticitybyamyloid-betaoligomers.Nature457,1128-1132.
Lemere,C.A.,andMasliah,E.(2010).CanAlzheimerdiseasebepreventedbyamyloid-betaimmunotherapy?NatRevNeurol6,108-119.
Lesne,S.,Koh,M.T.,Kotilinek,L.,Kayed,R.,Glabe,C.G.,Yang,A.,Gallagher,M.,andAshe,K.H.(2006).Aspecificamyloid-betaproteinassemblyinthebrainimpairsmemory.Nature440,352-357.
Levin,E.D.(2002).Nicotinicreceptorsubtypesandcognitivefunction.JNeurobiol53,633-640.
LiFM,D.X.,WangJJ,FangHL.(2008).EffectsofGinkgobilobaextractonMitoKATPinfocalcerebralischemia-reperfusionrats.ChinArchTraditChinMed26:1462-3.
Li,Y.C.,Yeh,C.H.,Yang,M.L.,andKuan,Y.H.(2012).LuteolinSuppressesInflammatoryMediatorExpressionbyBlockingtheAkt/NFkappaBPathwayinAcuteLungInjuryInducedbyLipopolysaccharideinMice.EvidBasedComplementAlternatMed2012,383608.
Liao,J.W.,Hsu,C.K.,Wang,M.F.,Hsu,W.M.,andChan,Y.C.(2006).BeneficialeffectofToonasinensisRoemoronimprovingcognitiveperformanceandbraindegenerationinsenescence-acceleratedmice.BrJNutr96,400-407.
Lim,G.P.,Yang,F.,Chu,T.,Chen,P.,Beech,W.,Teter,B.,Tran,T.,Ubeda,O.,Ashe,K.H.,Frautschy,S.A.,etal.(2000).IbuprofensuppressesplaquepathologyandinflammationinamousemodelforAlzheimer''sdisease.JNeurosci20,5709-5714.
Lin,H.,Bhatia,R.,andLal,R.(2001).Amyloidbetaproteinformsionchannels:implicationsforAlzheimer''sdiseasepathophysiology.FASEBJ15,2433-2444.
Ling,F.A.,Hui,D.Z.,andJi,S.M.(2007).Protectiveeffectofrecombinanthumansomatotropinonamyloidbeta-peptideinducedlearningandmemorydeficitsinmice.GrowthHormIGFRes17,336-341.
Liu,B.H.,Wang,X.,Ma,Y.X.,andWang,S.(2004).CMVenhancer/humanPDGF-betapromoterforneuron-specifictransgeneexpression.GeneTher11,52-60.
Loring,J.F.,Paszty,C.,Rose,A.,McIntosh,T.K.,Murai,H.,Pierce,J.E.,Schramm,S.R.,Wymore,K.,Lee,V.M.,Trojanowski,J.Q.,etal.(1996).RationaldesignofananimalmodelforAlzheimer''sdisease:introductionofmultiplehumangenomictransgenestoreproduceADpathologyinarodent.NeurobiolAging17,173-182.
Lu,M.C.,Hsieh,M.T.,Wu,C.R.,Cheng,H.Y.,Hsieh,C.C.,Lin,Y.T.,andPeng,W.H.(2007).Amelioratingeffectofemodin,aconstituteofPolygonatummultiflorum,oncycloheximide-inducedimpairmentofmemoryconsolidationinrats.JEthnopharmacol112,552-556.
Lv,J.,Jia,H.,Jiang,Y.,Ruan,Y.,Liu,Z.,Yue,W.,Beyreuther,K.,Tu,P.,andZhang,D.(2009).Tenuifolin,anextractderivedfromtenuigenin,inhibitsamyloid-betasecretioninvitro.ActaPhysiol(Oxf)196,419-425.
Ma,X.,Tan,C.,Zhu,D.,Gang,D.R.,andXiao,P.(2007).HuperzineAfromHuperziaspecies--anethnopharmacolgicalreview.JEthnopharmacol113,15-34.
Man,S.C.,Chan,K.W.,Lu,J.H.,Durairajan,S.S.,Liu,L.F.,andLi,M.(2012).Systematicreviewontheefficacyandsafetyofherbalmedicinesforvasculardementia.EvidBasedComplementAlternatMed2012,426215.
Manzerra,P.,Behrens,M.M.,Canzoniero,L.M.,Wang,X.Q.,Heidinger,V.,Ichinose,T.,Yu,S.P.,andChoi,D.W.(2001).ZincinducesaSrcfamilykinase-mediatedup-regulationofNMDAreceptoractivityandexcitotoxicity.ProcNatlAcadSciUSA98,11055-11061.
Maragos,W.F.,Chu,D.C.,Young,A.B.,D''Amato,C.J.,andPenney,J.B.,Jr.(1987).Lossofhippocampal[3H]TCPbindinginAlzheimer''sdisease.NeurosciLett74,371-376.
Mattson,M.P.(2004).PathwaystowardsandawayfromAlzheimer''sdisease.Nature430,631-639.
Mazza,M.,Capuano,A.,Bria,P.,andMazza,S.(2006).Ginkgobilobaanddonepezil:acomparisoninthetreatmentofAlzheimer''sdementiainarandomizedplacebo-controlleddouble-blindstudy.EurJNeurol13,981-985.
McCurry,S.M.,Pike,K.C.,Vitiello,M.V.,Logsdon,R.G.,Larson,E.B.,andTeri,L.(2011).Increasingwalkingandbrightlightexposuretoimprovesleepincommunity-dwellingpersonswithAlzheimer''sdisease:resultsofarandomized,controlledtrial.JAmGeriatrSoc59,1393-1402.
Medeiros,R.,Prediger,R.D.,Passos,G.F.,Pandolfo,P.,Duarte,F.S.,Franco,J.L.,Dafre,A.L.,DiGiunta,G.,Figueiredo,C.P.,Takahashi,R.N.,etal.(2007).ConnectingTNF-alphasignalingpathwaystoiNOSexpressioninamousemodelofAlzheimer''sdisease:relevanceforthebehavioralandsynapticdeficitsinducedbyamyloidbetaprotein.JNeurosci27,5394-5404.
Melo,J.B.,Agostinho,P.,andOliveira,C.R.(2003).Involvementofoxidativestressintheenhancementofacetylcholinesteraseactivityinducedbyamyloidbeta-peptide.NeurosciRes45,117-127.
Mimica,N.,andKalinic,D.(2011).Arttherapymaybebenefitialforreducingstress--relatedbehavioursinpeoplewithdementia--casereport.PsychiatrDanub23,125-128.
Mirouze,J.,Monnier,L.,andOlivier,C.(1975).Studyofrenalfunctionsbyrepeatedconstantinfusionofradiotracersbeforeandafterinitiationoftherapyinhypertensionorindiabetesmellitus.PatholBiol(Paris)23,599-603.
Mohs,R.C.,Doody,R.S.,Morris,J.C.,Ieni,J.R.,Rogers,S.L.,Perdomo,C.A.,andPratt,R.D.(2001).A1-year,placebo-controlledpreservationoffunctionsurvivalstudyofdonepezilinADpatients.Neurology57,481-488.
Monyer,H.,Burnashev,N.,Laurie,D.J.,Sakmann,B.,andSeeburg,P.H.(1994).DevelopmentalandregionalexpressionintheratbrainandfunctionalpropertiesoffourNMDAreceptors.Neuron12,529-540.
Moriguchi,S.,Marszalec,W.,Zhao,X.,Yeh,J.Z.,andNarahashi,T.(2004).MechanismofactionofgalantamineonN-methyl-D-aspartatereceptorsinratcorticalneurons.JPharmacolExpTher310,933-942.
Morris,R.(1984).Developmentsofawater-mazeprocedureforstudyingspatiallearningintherat.JNeurosciMethods11,47-60.
Morris,R.G.,andKopelman,M.D.(1986).ThememorydeficitsinAlzheimer-typedementia:areview.QJExpPsycholA38,575-602.
Mowszowski,L.,Batchelor,J.,andNaismith,S.L.(2010).Earlyinterventionforcognitivedecline:cancognitivetrainingbeusedasaselectivepreventiontechnique?IntPsychogeriatr22,537-548.
Mulder,J.,Harkany,T.,Czollner,K.,Cremers,T.I.,Keijser,J.N.,Nyakas,C.,andLuiten,P.G.(2005).Galantamine-inducedbehavioralrecoveryaftersublethalexcitotoxiclesionstotheratmedialseptum.BehavBrainRes163,33-41.
Munch,G.,Schinzel,R.,Loske,C.,Wong,A.,Durany,N.,Li,J.J.,Vlassara,H.,Smith,M.A.,Perry,G.,andRiederer,P.(1998).Alzheimer''sdisease-synergisticeffectsofglucosedeficit,oxidativestressandadvancedglycationendproducts.JournalofNeuralTransmission105,439-461.
Mura,T.,Dartigues,J.F.,andBerr,C.(2010).HowmanydementiacasesinFranceandEurope?Alternativeprojectionsandscenarios2010-2050.EuropeanJournalofNeurology17,252-259.
Murray,C.L.,andFibiger,H.C.(1985).Learningandmemorydeficitsafterlesionsofthenucleusbasalismagnocellularis:reversalbyphysostigmine.Neuroscience14,1025-1032.
Nitta,A.,Fukuta,T.,Hasegawa,T.,andNabeshima,T.(1997).Continuousinfusionofbeta-amyloidproteinintotheratcerebralventricleinduceslearningimpairmentandneuronalandmorphologicaldegeneration.JpnJPharmacol73,51-57.
Nitta,A.,Itoh,A.,Hasegawa,T.,andNabeshima,T.(1994).beta-Amyloidprotein-inducedAlzheimer''sdiseaseanimalmodel.NeurosciLett170,63-66.
Niwa,K.,Carlson,G.A.,andIadecola,C.(2000).ExogenousAbeta1-40reproducescerebrovascularalterationsresultingfromamyloidprecursorproteinoverexpressioninmice.JCerebrBloodFMet20,1659-1668.
Nomura,I.,Kato,N.,Kita,T.,andTakechi,H.(2005).Mechanismofimpairmentoflong-termpotentiationbyamyloidbetaisindependentofNMDAreceptorsorvoltage-dependentcalciumchannelsinhippocampalCA1pyramidalneurons.NeuroscienceLetters391,1-6.
Ohno,M.,andWatanabe,S.(1996).Ischemictolerancetomemoryimpairmentassociatedwithhippocampalneuronaldamageaftertransientcerebralischemiainrats.BrainResBull40,229-236.
Olney,J.W.,Wozniak,D.F.,andFarber,N.B.(1997).ExcitotoxicneurodegenerationinAlzheimerdisease.Newhypothesisandnewtherapeuticstrategies.ArchNeurol54,1234-1240.
Orgogozo,J.M.,Gilman,S.,Dartigues,J.F.,Laurent,B.,Puel,M.,Kirby,L.C.,Jouanny,P.,Dubois,B.,Eisner,L.,Flitman,S.,etal.(2003).SubacutemeningoencephalitisinasubsetofpatientswithADafterAbeta42immunization.Neurology61,46-54.
Ott,B.R.,andOwens,N.J.(1998).ComplementaryandalternativemedicinesforAlzheimer''sdisease.JGeriatrPsychiatryNeurol11,163-173.
Palmer,A.M.,andGershon,S.(1990).IstheneuronalbasisofAlzheimer''sdiseasecholinergicorglutamatergic?FASEBJ4,2745-2752.
Panza,F.,Frisardi,V.,Solfrizzi,V.,Imbimbo,B.P.,Logroscino,G.,Santamato,A.,Greco,A.,Seripa,D.,andPilotto,A.(2012).ImmunotherapyforAlzheimer''sdisease:fromanti-beta-amyloidtotau-basedimmunizationstrategies.Immunotherapy4,213-238.
Pappolla,M.A.,Sos,M.,Omar,R.A.,Bick,R.J.,Hickson-Bick,D.L.,Reiter,R.J.,Efthimiopoulos,S.,andRobakis,N.K.(1997).MelatoninpreventsdeathofneuroblastomacellsexposedtotheAlzheimeramyloidpeptide.JNeurosci17,1683-1690.
Parameshwaran,K.,Dhanasekaran,M.,andSuppiramaniam,V.(2008).Amyloidbetapeptidesandglutamatergicsynapticdysregulation.ExpNeurol210,7-13.
Parle,M.,andSingh,N.(2004).Animalmodelsfortestingmemory.AsiaPacificJPharmacol,16:101–120.
Parri,R.H.,andDineley,T.K.(2010).Nicotinicacetylcholinereceptorinteractionwithbeta-amyloid:molecular,cellular,andphysiologicalconsequences.CurrAlzheimerRes7,27-39.
PaxinosG,W.C.(2006).Theratbraininstereotaxiccoordinates.SanDiego,CA:Elsevier.
Peila,R.,Rodriguez,B.L.,andLauner,L.J.(2002).Type2diabetes,APOEgene,andtheriskfordementiaandrelatedpathologies:TheHonolulu-AsiaAgingStudy.Diabetes51,1256-1262.
Peng,Y.,Xing,C.H.,Xu,S.F.,Lemere,C.A.,Chen,G.Q.,Liu,B.,Wang,L.,Feng,Y.P.,andWang,X.L.(2009).L-3-n-butylphthalideimprovescognitiveimpairmentinducedbyintracerebroventricularinfusionofamyloid-betapeptideinrats.EuropeanJournalofPharmacology621,38-45.
Perry,E.K.,Tomlinson,B.E.,Blessed,G.,Bergmann,K.,Gibson,P.H.,andPerry,R.H.(1978).Correlationofcholinergicabnormalitieswithsenileplaquesandmentaltestscoresinseniledementia.BrMedJ2,1457-1459.
Prediger,R.D.,Medeiros,R.,Pandolfo,P.,Duarte,F.S.,Passos,G.F.,Pesquero,J.B.,Campos,M.M.,Calixto,J.B.,andTakahashi,R.N.(2008).GeneticdeletionorantagonismofkininB(1)andB(2)receptorsimprovescognitivedeficitsinamousemodelofAlzheimer''sdisease.Neuroscience151,631-643.
Qizilbash,N.,Birks,J.,LopezArrieta,J.,Lewington,S.,andSzeto,S.(2007).WITHDRAWN:TacrineforAlzheimer''sdisease.CochraneDatabaseSystRev,CD000202.
Querfurth,H.W.,andLaferla,F.M.(2010).Alzheimer''sDiseaseREPLY.NewEnglJMed362,1844-1845.
Raskind,M.A.,Peskind,E.R.,Truyen,L.,Kershaw,P.,andDamaraju,C.V.(2004).Thecognitivebenefitsofgalantaminearesustainedforatleast36months:along-termextensiontrial.ArchNeurol61,252-256.
Raskind,M.A.,Peskind,E.R.,Wessel,T.,andYuan,W.(2000).GalantamineinAD:A6-monthrandomized,placebo-controlledtrialwitha6-monthextension.TheGalantamineUSA-1StudyGroup.Neurology54,2261-2268.
Rees,T.,Hammond,P.I.,Soreq,H.,Younkin,S.,andBrimijoin,S.(2003).Acetylcholinesterasepromotesbeta-amyloidplaquesincerebralcortex.NeurobiolAging24,777-787.
Rees,T.M.,andBrimijoin,S.(2003).TheroleofacetylcholinesteraseinthepathogenesisofAlzheimer''sdisease.DrugsToday(Barc)39,75-83.
Repantis,D.,Laisney,O.,andHeuser,I.(2010).Acetylcholinesteraseinhibitorsandmemantineforneuroenhancementinhealthyindividuals:asystematicreview.PharmacolRes61,473-481.
Retz,W.,Gsell,W.,Munch,G.,andRiederer,P.(1998).FreeradicalsinAlzheimer''sdisease.JNeuralTransm-Supp,221-236.
Ringman,J.M.,Frautschy,S.A.,Cole,G.M.,Masterman,D.L.,andCummings,J.L.(2005).ApotentialroleofthecurryspicecurcumininAlzheimer''sdisease.CurrAlzheimerRes2,131-136.
Ronicke,R.,Klemm,A.,Meinhardt,J.,Schroder,U.H.,Fandrich,M.,andReymann,K.G.(2008).AbetaMediatedDiminutionofMTTReduction-AnArtefactofSingleCellCulture?PlosOne3.
Rosales-Corral,S.,Tan,D.X.,Reiter,R.J.,Valdivia-Velazquez,M.,Acosta-Martinez,J.P.,andOrtiz,G.G.(2004).Kineticsoftheneuroinflammation-oxidativestresscorrelationinratbrainfollowingtheinjectionoffibrillaramyloid-betaonto
摘要: 阿茲海默醫師於一百年前首次揭露失智症的獨特症狀與腦中病理特色。
現今,阿茲海默症已佔所有失智症一半以上,也成為老年人健康問題的第三名。
在美國,阿茲海默症是死亡原因的第六名,估計2012年間照顧者可能為照顧各種失智症患者花費200億美元。
迄今,阿茲海默症的機轉亦未完全了解。
「類澱粉階梯理論」(amyloidcascadehypothesis)敘述了阿茲海默症形成之步驟。
然而目前美國食品管理局核可治療阿茲海默症藥物有二種,一為乙醯膽鹼水解醑制劑,另一為NMDA受體拮抗劑。
雖然研究顯示此兩類藥物均比安慰劑但更可維持認知功能,但是它們僅是改善疾病過程,並有許多副作用。
本研究基於「類澱粉階梯理論」(amyloidcascadehypothesis)而設計,利用乙型類澱粉胜(b-amyloidpeptide;Ab)經由立體定位與微小幫浦注入大鼠腦室誘發行為及學習障礙,藉以了解益氣聰明湯對乙型類澱粉胜誘發行為及學習障礙改善作用。
而研究結果發現在分組治療與對照組服用益氣聰明湯的老鼠學習及行為比對照組好很多,而且鼠腦切片分析不只發現乙型類澱粉斑塊也減少,乙醯膽鹼分泌與NMDA受體亦有增加之情形,所以顯示益氣聰明湯可減輕乙型類澱粉誘發的學習障礙。
AloisAlzheimerdescribedthetypicalsymptomsandsignsofdementia,andfirstnotedthecharacteristicpathologicpictureinthedementiabrainonehundredyearsago.Sofar,Alzheimer’sdiseaseisresponsibleforabove50%ofallfindsofdementia,isalsothethirdgreatedheathproblemintheelders.InAmerican,Alzheimer’sdiseaseisthesixthleadingcauseofdeath,aswellpaymeatsformedicare,longtermcareforAlzheimer’sdiseaseandotherdementiaareanticipatedmorethan200billionUSdollarsin2012.TheprecisemechanismbehindAlzheimer’sdiseaseisnotyetdisclosedcompletely,「amyloidcascadehypothesis」isthemostpredominantmodelforunderstandingthepathophysiologyofAlzheimer’sdisease.However,therearetwotypeofmedicineswereprovedbyUSFDAforthetreatmentofAlzheimer’sdisease;acetylcholinesteraseinhibitorsandN-methyl-D-aspartatereceptorantagonist.Thoughbothofthemcanmaintainhigherlevelofcognitivefunctioncomparedwithplacebo,theyareonlydisease-modifyingwithmultipleadverseeffects.Ourexperimentwasdesignedbasedon“amyloidcascadehypothesis”,thatiswidelyusedforexplanationofAlzheimer’sdiseasepathogenesis,whoseanimalmodelwithAlzheimer’sdisease-likephenotypewasdevelopedbyinfusionA(1-40)inratsbrains.Therearetwoprotocolsinourstudy,oneispreventive,theotheristherapeutic;whichourmedicationisYi-Chi-Tsung-Ming-Tang(YCTMT),adecoctioniscomposedofAstragaliradix,Ginsergradix,Pueratiaeradix,Paeoniaelactiforae,Phelloadendriconex,Viticisfructus,CimicifugaeuralensisandGlycyrrhizauralenss.OurresultsdemonstratedtheameliorativeeffectofYCTMTonA(1-40)inducedlearningimpairment.OraladministrationofYCYMTonratsappearstobeabletoprotectA-impairedmemoryretention,spatiallearningandmemory,aswellpromoteexpressionofacetylcholineandNMDARs.Therefore,thetherapeuticprotentialofYCTMYinAlzheimer’sdiseasemeritsfurtherinvestigation.
URI: http://hdl.handle.net/11455/20302
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