16S rRNA sequencingOpen reading frameRibosome binding siteKozak sequenceShine Dalgarnoshine dalgarno sequence中文

The Shine-Dalgarno sequence - Research School of Biology

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This ribosomal binding site in bacterial messenger RNA became known as the Shine-Dalgarno (SD) sequence. It enables initiation of protein synthesis by ... Skipnavigation ResearchSchoolofBiologyANUCollegeofScience Searchquery SearchANUweb,staff&mapsSearchcurrentsitecontent Search CurrentstudentsIntranetStaffloginStaffservices HomeStudyResearchPeopleNews&eventsAboutContacts Menu Searchquery Search HomeStudyBachelordegrees&honoursMasterdegreesPhD&MPhilCoursesStudentprojectsStudentprofilesBiologyTeachingandLearningCentreHonoursRSBStudentscholarships&prizesAnjeliNathanMemorialScholarshipHirotoNaoraGraduateStudentTravelScholarshipJanAndersonANU-NTUHDRSupplementaryScholarshipRSBDirector’sPrizeinHonoursRSBOutstandingThesisPrizeSummerResearchScholarshipsInternationalstudentscholarshipsSchoolenrichment&outreachResourcesforschoolsResearchDivisionsResearchgroupsHonorarygroupsCentres&unitsFacilitiesProjectsResearchstoriesResources&toolsThemesPeopleAllpeopleAcademicsVisitorsStudentsProfessionalstaffVolunteersNews&eventsNewsEventsPasteventsEventseriesCalendarEventrecordingsNewslettersAboutOrganisationalstructureAwardsAllAwardsRalphSlatyerMedalThehistoryofBiologyatANUInclusion,Diversity,EquityandAccessContactsFuturestudentsenquiriesCurrentstudentsenquiriesGeneralenquiriesServicesCurrentstudentsIntranetStaffloginStaffservicesConnectingtotheRSBVPNservice SearchANUweb,staff&maps Searchcurrentsitecontent close StudyDiscoverourdegreeprogramsandcourses. Bachelordegrees&honoursMasterdegreesPhD&MPhilCoursesStudentprojectsStudentprofilesBiologyTeachingandLearningCentreHonoursRSBStudentscholarships&prizesSchoolenrichment&outreach close ResearchReadaboutourresearch. DivisionsResearchgroupsCentres&unitsFacilitiesProjectsResearchstoriesResources&toolsThemes close PeopleAdirectoryofallmembersoftheResearchSchoolofBiology. AllpeopleAcademicsVisitorsStudentsProfessionalstaffVolunteers close News&eventsFindoutabouttheschool'slatestnewsandevents. NewsEventsEventseriesCalendarEventrecordingsNewsletters close AboutReadabouttheschool'shistory,governanceandstructure. OrganisationalstructureAwardsRalphSlatyerMedalThehistoryofBiologyatANUInclusion,Diversity,EquityandAccess close ContactsGetintouchwithus. FuturestudentsenquiriesCurrentstudentsenquiriesGeneralenquiriesServices Youarehere»News&events»News»TheShine-Dalgarnosequence-thebeginningsofbiotechnology TheShine-Dalgarnosequence-thebeginningsofbiotechnology Manyproteinsrequiredforbiotechnologicalormedicalpurposes(forexample,insulin,enzymes,hormonesetc)areproducedinbacteria. In1973,LynnDalgarno,fromtheANUDepartmentofBiochemistry,andhisPhDstudentJohnShine,proposedaninitiatingsignalforproteinsynthesisinprokaryoticcells.ThisribosomalbindingsiteinbacterialmessengerRNAbecameknownastheShine-Dalgarno(SD)sequence.Itenablesinitiationofproteinsynthesisbyaligningtheribosomewiththestartcodon. Simplyput,genesarereadingroupsofthreeletters,butyouneedtolettheribosomeknowwheretostart.Forexample,ifyouread“Ourdogcanseethecat”,itmakessense,butifyoushiftthestartingpointbyoneletter,itbecomes“urdogcanseethecato”.TheSDsequencetellsthebacteriawheretostartproteinsynthesissothatthegenesarereadcorrectly. ReadtheoriginalNaturearticlehere. Thisarticleisoneofasetfeaturingtheachievementsandmemorableoccasionsin theHistoryofBiologyat ANU. Readalso Wildanimalsevolvingmuchfasterthanpreviouslythought » Wildanimalsareevolvingfasterthananybody thought » Newhorizons:whatcanabiologistbringtothestudyoflanguageendangerment? » Share ContactANU Copyright Disclaimer Privacy FreedomofInformation +61261255111 TheAustralianNationalUniversity,Canberra CRICOSProvider:00120C ABN:52234063906 YouappeartobeusingInternetExplorer7,orhavecompatibilityviewturnedon.YourbrowserisnotsupportedbyANUwebstyles.»Learnhowtofixthis »Ignorethiswarninginfuture

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