Plasma Aldosterone after Seated Saline Infusion ... - Elsevier

OBJECTIVE: The saline infusion test (SIT) and the captopril test (CT) are widely used as confirmatory tests for primary aldosteronism (PA). 跳至主導覽 跳至搜尋 跳過主要內容 PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism CheHsiungWu,VincentWu,YaWenYang,YenHungLin,ShaoYuYang,PoChihLin,ChinChenChang,YaoChouTsai,ShuoMengWang 研究成果:雜誌貢獻›文章›同行評審 3 引文 斯高帕斯（Scopus） 總覽 指紋 摘要 OBJECTIVE:Thesalineinfusiontest(SIT)andthecaptopriltest(CT)arewidelyusedasconfirmatorytestsforprimaryaldosteronism(PA).Wehypothesizedthatpost-SITandpost-CTplasmaaldosteroneconcentrations(PAC)indicatetheseverityofaldosterone-producingadenoma(APA)andmightpredictclinicaloutcome.METHODS:Werecruited216patientswithAPAintheTaiwanPrimaryAldosteronismInvestigation(TAIPAI)registrywhoreceivedbothseatedSITandCTasconfirmatorytests.Thedataof143patientswhounderwentadrenalectomywithcompletefollow-upafterdiagnosiswereincludedinthefinalanalysis.WedeterminedtheproportionofpatientsachievingclinicalsuccessinaccordancewiththePrimaryAldosteronismSurgicalOutcomeconsensus.Logisticregressionanalysiswasconductedtoidentifypreoperativefactorsassociatedwithcureofhypertension.RESULTS:Completeclinicalsuccesswasachievedin48(33.6%)patientsandpartialclinicalsuccessin59(41.2%)patients;absentclinicalsuccesswasseenin36(25.2%)of143patients.Post-SITPACbutnotpost-CTPACwasindependentlyassociatedwithclinicaloutcome.Higherlevelsofpost-SITPAChadahigherlikelihoodofclinicalbenefit(completepluspartialclinicalsuccess;oddsratio=1.04perng/dlincrease,95%confidenceinterval=1.01,1.06;P=0.004).Patientswithpost-SITPAC>25ng/dlweremorelikelytohaveafavorableclinicaloutcomeafteradrenalectomy.Thiscutoffvaluetranslatedintoapositivepredictivevalueof86.0%.CONCLUSIONS:Wesuggestthatpost-SITPACisabetterpredictorthanpost-CTPACforclinicalsuccessinPApostadrenalectomy. 原文英語頁（從-到）1066-1074頁數9期刊AmericanJournalofHypertension卷32發行號11DOIshttps://doi.org/10.1093/ajh/hpz098出版狀態已發佈-十月162019對外發佈是 ASJCScopussubjectareas內科學 存取文件 10.1093/ajh/hpz098 其它文件與鏈接 LinktopublicationinScopus Hyperaldosteronism Medicine&LifeSciences 100% Captopril Medicine&LifeSciences 93% Adrenalectomy Medicine&LifeSciences 90% Aldosterone Medicine&LifeSciences 81% Adenoma Medicine&LifeSciences 16% Taiwan Medicine&LifeSciences 8% Registries Medicine&LifeSciences 6% RegressionAnalysis Medicine&LifeSciences 5% 引用此 APA Standard Harvard Vancouver Author BIBTEX RIS Wu,C.H.,Wu,V.,Yang,Y.W.,Lin,Y.H.,Yang,S.Y.,Lin,P.C.,Chang,C.C.,Tsai,Y.C.,&Wang,S.M.(2019).PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism.AmericanJournalofHypertension,32(11),1066-1074.https://doi.org/10.1093/ajh/hpz098 PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism./Wu,CheHsiung;Wu,Vincent;Yang,YaWen;Lin,YenHung;Yang,ShaoYu;Lin,PoChih;Chang,ChinChen;Tsai,YaoChou;Wang,ShuoMeng.於:AmericanJournalofHypertension,卷32,編號11,16.10.2019,p.1066-1074.研究成果:雜誌貢獻›文章›同行評審 Wu,CH,Wu,V,Yang,YW,Lin,YH,Yang,SY,Lin,PC,Chang,CC,Tsai,YC&Wang,SM2019,'PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism',AmericanJournalofHypertension,卷32,編號11,頁1066-1074.https://doi.org/10.1093/ajh/hpz098 WuCH,WuV,YangYW,LinYH,YangSY,LinPC等.PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism.AmericanJournalofHypertension.201910月16;32(11):1066-1074.https://doi.org/10.1093/ajh/hpz098 Wu,CheHsiung;Wu,Vincent;Yang,YaWen;Lin,YenHung;Yang,ShaoYu;Lin,PoChih;Chang,ChinChen;Tsai,YaoChou;Wang,ShuoMeng./PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism.於:AmericanJournalofHypertension.2019;卷32,編號11.頁1066-1074. @article{6a87c226c28446e19ccbc4703aeb7b2e,title="PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronism",abstract="OBJECTIVE:Thesalineinfusiontest(SIT)andthecaptopriltest(CT)arewidelyusedasconfirmatorytestsforprimaryaldosteronism(PA).Wehypothesizedthatpost-SITandpost-CTplasmaaldosteroneconcentrations(PAC)indicatetheseverityofaldosterone-producingadenoma(APA)andmightpredictclinicaloutcome.METHODS:Werecruited216patientswithAPAintheTaiwanPrimaryAldosteronismInvestigation(TAIPAI)registrywhoreceivedbothseatedSITandCTasconfirmatorytests.Thedataof143patientswhounderwentadrenalectomywithcompletefollow-upafterdiagnosiswereincludedinthefinalanalysis.WedeterminedtheproportionofpatientsachievingclinicalsuccessinaccordancewiththePrimaryAldosteronismSurgicalOutcomeconsensus.Logisticregressionanalysiswasconductedtoidentifypreoperativefactorsassociatedwithcureofhypertension.RESULTS:Completeclinicalsuccesswasachievedin48(33.6%)patientsandpartialclinicalsuccessin59(41.2%)patients;absentclinicalsuccesswasseenin36(25.2%)of143patients.Post-SITPACbutnotpost-CTPACwasindependentlyassociatedwithclinicaloutcome.Higherlevelsofpost-SITPAChadahigherlikelihoodofclinicalbenefit(completepluspartialclinicalsuccess;oddsratio=1.04perng/dlincrease,95%confidenceinterval=1.01,1.06;P=0.004).Patientswithpost-SITPAC>25ng/dlweremorelikelytohaveafavorableclinicaloutcomeafteradrenalectomy.Thiscutoffvaluetranslatedintoapositivepredictivevalueof86.0%.CONCLUSIONS:Wesuggestthatpost-SITPACisabetterpredictorthanpost-CTPACforclinicalsuccessinPApostadrenalectomy.",keywords="adrenalectomy,bloodpressure,hypertension,outcome,primaryaldosteronism",author="Wu,{CheHsiung}andVincentWuandYang,{YaWen}andLin,{YenHung}andYang,{ShaoYu}andLin,{PoChih}andChang,{ChinChen}andTsai,{YaoChou}andWang,{ShuoMeng}",year="2019",month=oct,day="16",doi="10.1093/ajh/hpz098",language="English",volume="32",pages="1066--1074",journal="AmericanJournalofHypertension",issn="0895-7061",publisher="OxfordUniversityPress",number="11",} TY-JOURT1-PlasmaAldosteroneafterSeatedSalineInfusionTestOutperformsCaptoprilTestatPredictingClinicalOutcomesafterAdrenalectomyforPrimaryAldosteronismAU-Wu,CheHsiungAU-Wu,VincentAU-Yang,YaWenAU-Lin,YenHungAU-Yang,ShaoYuAU-Lin,PoChihAU-Chang,ChinChenAU-Tsai,YaoChouAU-Wang,ShuoMengPY-2019/10/16Y1-2019/10/16N2-OBJECTIVE:Thesalineinfusiontest(SIT)andthecaptopriltest(CT)arewidelyusedasconfirmatorytestsforprimaryaldosteronism(PA).Wehypothesizedthatpost-SITandpost-CTplasmaaldosteroneconcentrations(PAC)indicatetheseverityofaldosterone-producingadenoma(APA)andmightpredictclinicaloutcome.METHODS:Werecruited216patientswithAPAintheTaiwanPrimaryAldosteronismInvestigation(TAIPAI)registrywhoreceivedbothseatedSITandCTasconfirmatorytests.Thedataof143patientswhounderwentadrenalectomywithcompletefollow-upafterdiagnosiswereincludedinthefinalanalysis.WedeterminedtheproportionofpatientsachievingclinicalsuccessinaccordancewiththePrimaryAldosteronismSurgicalOutcomeconsensus.Logisticregressionanalysiswasconductedtoidentifypreoperativefactorsassociatedwithcureofhypertension.RESULTS:Completeclinicalsuccesswasachievedin48(33.6%)patientsandpartialclinicalsuccessin59(41.2%)patients;absentclinicalsuccesswasseenin36(25.2%)of143patients.Post-SITPACbutnotpost-CTPACwasindependentlyassociatedwithclinicaloutcome.Higherlevelsofpost-SITPAChadahigherlikelihoodofclinicalbenefit(completepluspartialclinicalsuccess;oddsratio=1.04perng/dlincrease,95%confidenceinterval=1.01,1.06;P=0.004).Patientswithpost-SITPAC>25ng/dlweremorelikelytohaveafavorableclinicaloutcomeafteradrenalectomy.Thiscutoffvaluetranslatedintoapositivepredictivevalueof86.0%.CONCLUSIONS:Wesuggestthatpost-SITPACisabetterpredictorthanpost-CTPACforclinicalsuccessinPApostadrenalectomy.AB-OBJECTIVE:Thesalineinfusiontest(SIT)andthecaptopriltest(CT)arewidelyusedasconfirmatorytestsforprimaryaldosteronism(PA).Wehypothesizedthatpost-SITandpost-CTplasmaaldosteroneconcentrations(PAC)indicatetheseverityofaldosterone-producingadenoma(APA)andmightpredictclinicaloutcome.METHODS:Werecruited216patientswithAPAintheTaiwanPrimaryAldosteronismInvestigation(TAIPAI)registrywhoreceivedbothseatedSITandCTasconfirmatorytests.Thedataof143patientswhounderwentadrenalectomywithcompletefollow-upafterdiagnosiswereincludedinthefinalanalysis.WedeterminedtheproportionofpatientsachievingclinicalsuccessinaccordancewiththePrimaryAldosteronismSurgicalOutcomeconsensus.Logisticregressionanalysiswasconductedtoidentifypreoperativefactorsassociatedwithcureofhypertension.RESULTS:Completeclinicalsuccesswasachievedin48(33.6%)patientsandpartialclinicalsuccessin59(41.2%)patients;absentclinicalsuccesswasseenin36(25.2%)of143patients.Post-SITPACbutnotpost-CTPACwasindependentlyassociatedwithclinicaloutcome.Higherlevelsofpost-SITPAChadahigherlikelihoodofclinicalbenefit(completepluspartialclinicalsuccess;oddsratio=1.04perng/dlincrease,95%confidenceinterval=1.01,1.06;P=0.004).Patientswithpost-SITPAC>25ng/dlweremorelikelytohaveafavorableclinicaloutcomeafteradrenalectomy.Thiscutoffvaluetranslatedintoapositivepredictivevalueof86.0%.CONCLUSIONS:Wesuggestthatpost-SITPACisabetterpredictorthanpost-CTPACforclinicalsuccessinPApostadrenalectomy.KW-adrenalectomyKW-bloodpressureKW-hypertensionKW-outcomeKW-primaryaldosteronismUR-http://www.scopus.com/inward/record.url?scp=85073311381&partnerID=8YFLogxKUR-http://www.scopus.com/inward/citedby.url?scp=85073311381&partnerID=8YFLogxKU2-10.1093/ajh/hpz098DO-10.1093/ajh/hpz098M3-ArticleC2-31216359AN-SCOPUS:85073311381VL-32SP-1066EP-1074JO-AmericanJournalofHypertensionJF-AmericanJournalofHypertensionSN-0895-7061IS-11ER-